3,6,9,12-Tetramethyl-2,5,8,11,14-pentaoxapentadecane | 116646-26-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,12-Tetramethyl-2,5,8,11,14-pentaoxapentadecane
• 英文别名: 1-methoxy-2-[2-[2-(2-methoxypropoxy)propoxy]propoxy]propane
• CAS: 116646-26-5
• 化学式: C₁₄H₃₀O₅
• 分子量: 278.38
• InChiKey: ROSYHLFNMZTEKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PROCESS FOR PREPARING ISOCYANATES BY THERMALLY CLEAVING CARBAMATES
  申请人：Bock Michael

  公开号：US20120245377A1

  公开（公告）日：2012-09-27

  A process is proposed for preparing isocyanates by thermally cleaving carbamates to obtain a carbamate cleavage gas comprising the corresponding isocyanate and the corresponding alcohol, which comprises quenching the carbamate cleavage gas in the presence of an ether which functions as an inhibitor for the reverse reaction of the isocyanate with the alcohol.

  提出了一种制备异氰酸酯的过程，通过热解氨基甲酸酯来获得含有相应异氰酸酯和相应醇的氨基甲酸酯裂解气体，其中包括在醚的存在下淬灭氨基甲酸酯裂解气体，该醚作为异氰酸酯与醇的反应的逆反应的抑制剂。
• Process for polymerizing a methacrylic ester or an acrylic ester
  申请人：Kuraray Co., Ltd.

  公开号：US20030204033A1

  公开（公告）日：2003-10-30

  (1) A methacrylic ester or an acrylic ester is anionically polymerized, using a polymerization initiator compound comprising an addition reaction product of a conjugated diene compound and an organic alkali metal compound, in the presence of a tertiary organoaluminum compound having in the molecule thereof a chemical structure represented by a formula: Al—O—Ar wherein Ar represents an aromatic ring; or (2) a methacrylic ester or an acrylic ester is anionically polymerized, using a polymerization initiator compound comprising an addition reaction product of an organic alkali metal compound and a compound having a 1,1-diaryl-1-alkene structure, by adding the ester in the form of a mixture with the above-mentioned specific tertiary organoaluminum compound to the polymerization system. In this way, various species of the esters can be anionically polymerized with a high initiation efficiency and a high living polymerization property in a solvent which can easily be recovered and reused under a mild cooling condition, using an organic alkali metal compound which has relatively good convenience.

  (1) 采用聚二烯化合物和有机碱金属化合物的加成反应产物组成的聚合引发剂化合物，在三级有机铝化合物的存在下，阴离子聚合甲基丙烯酸酯或丙烯酸酯，该三级有机铝化合物的分子中具有以下化学结构的公式：Al-O-Ar，其中Ar代表芳香环；或 (2) 采用有机碱金属化合物和具有1,1-二芳基-1-烯烃结构的化合物的加成反应产物组成的聚合引发剂化合物，将酯以与上述特定三级有机铝化合物的混合物形式添加到聚合体系中，从而在可以轻松回收和在温和冷却条件下重复使用的溶剂中，使用相对方便的有机碱金属化合物高效引发各种酯的阴离子聚合，并具有高活性聚合性能。
• Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment
  申请人：Kosutic Gordana

  公开号：US20070213262A1

  公开（公告）日：2007-09-13

  A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin. The compositions of this invention are useful in the treatment of various bone disorders and pain.

  本发明揭示了一种混合物，其中混合物中的每个共轭物包括与寡聚物偶联的降钙素药物，该寡聚物包括聚烷基乙二醇基团。该混合物可以通过10％、15％甚至20％或更多地降低受试者的血清钙水平。此外，该混合物可能比非共轭的降钙素更有效地在体外肠道消化模型中存活。此外，该混合物可能表现出比非共轭的降钙素更高的生物利用度。本发明的组合物在治疗各种骨骼疾病和疼痛方面有用。
• MIXTURES OF DRUG-OLIGOMER CONJUGATES COMPRISING POLYETHYLENE GLYCOL, USES THEREOF, AND METHODS OF MAKING SAME
  申请人：Ekwuribe Nnochiri N.

  公开号：US20080312135A1

  公开（公告）日：2008-12-18

  A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.

  本发明揭示了一种非多分散混合物，其中混合物中的每个共轭物都包括一个药物偶联到一个包含聚乙二醇基团的寡聚物。该混合物可能表现出比类似共轭物的多分散混合物更高的体内活性。该混合物可能比类似共轭物的多分散混合物更有效地在体外肠消化模型中存活。该混合物可能导致比类似共轭物的多分散混合物更少的受试者间变异性。
• PROCESS FOR CLEANING WAFERS
  申请人：KUMON Soichi

  公开号：US20120211025A1

  公开（公告）日：2012-08-23

  A process for cleaning a wafer having an uneven pattern at its surface. The process includes at least the steps of: cleaning the wafer with a cleaning liquid; substituting the cleaning liquid retained in recessed portions of the wafer with a water-repellent liquid chemical after cleaning; and drying the wafer, wherein the cleaning liquid contains 80 mass % or greater of a solvent having a boiling point of 55 to 200° C., and wherein the water-repellent liquid chemical supplied in the substitution step has a temperature of not lower than 40° C. and lower than a boiling point of the water-repellent liquid chemical thereby imparting water repellency at least to surfaces of the recessed portions.

  一种清洗具有不平整表面的晶圆的方法。该方法至少包括以下步骤：使用清洗液清洗晶圆；在清洗后，用一种防水液体化学物质替换晶圆凹陷部分中保留的清洗液；并将晶圆干燥，其中，清洗液含有80质量%或更多沸点在55至200℃之间的溶剂，替换步骤中提供的防水液体化学物质的温度不低于40℃且低于防水液体化学物质的沸点，从而至少赋予凹陷部分表面防水性。