Oliose | 6988-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Oliose
• 英文别名: D-lyxo-2,6-dideoxy-hexose；2-deoxyfucose；(3R,4S,5R)-3,4,5-trihydroxyhexanal
• CAS: 6988-56-3
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: JWFRNGYBHLBCMB-PBXRRBTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] GLYCOSYLATED CARDIOTONIC STEROIDS<br/>[FR] STÉROÏDES CARDIOTONIQUES GLYCOSYLÉS
  申请人：UNIV NORTHEASTERN

  公开号：WO2014194068A1

  公开（公告）日：2014-12-04

  Compounds which are glycosylates of an A-ring of a cardiotonic steroid, wherein the steroid is attached to the anomeric position of (a) a monosaccharide comprising a C-4 amino group, or (b) an oligosaccharide are provided.

  提供了一种心力衰竭类固醇A环的糖基化化合物，其中类固醇连接到（a）包含C-4氨基团的单糖的环氧位置，或（b）寡糖的环氧位置。
• [EN] INHIBITORS OF PSEUDOMONAS AERUGINOSA LECB<br/>[FR] INHIBITEURS DE PSEUDOMONAS AERUGINOSA LECB
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH

  公开号：WO2016151066A1

  公开（公告）日：2016-09-29

  The present invention relates to compounds derived from deoxy fucose. These compounds are useful as lectin inhibitors, especially as inhibitors of LecB. The invention also relates to pharmaceutical compositions comprising these compounds. The invention further relates to therapeutic uses of these compounds, especially to the prophylaxis or treatment of infections involving Pseudomonas aeruginosa.

  本发明涉及源自脱氧呋喃糖的化合物。这些化合物可作为凝集素抑制剂，特别是作为LecB的抑制剂。该发明还涉及包含这些化合物的药物组合物。此外，该发明还涉及这些化合物的治疗用途，特别是用于预防或治疗涉及铜绿假单胞菌感染的情况。
• Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds
  申请人：EPFL Ecole Polytechnique Fédérale de Lausanne

  公开号：EP2067771A1

  公开（公告）日：2009-06-10

  The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotinamide phosphoribosyl transferase.

  本发明涉及一种二羟基吡咯烷衍生物，可用于癌症治疗。该发明还涉及一种制备该化合物的方法。该化合物是α甘露糖苷酶的抑制剂，可能也抑制烟酰胺磷酸核糖转移酶。
• [EN] USE OF 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE TO PREPARE 2-DEOXYFUCOSE, ANALOGUES AND DERIVATIVES<br/>[FR] UTILISATION DE 2-DESOXYRIBOSE-5-PHOSPHATE ALDOLASE POUR LA PREPARATION DE 2-DESOXYFUCOSE, D'ANALOGUES ET DE DERIVES.
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：WO1996031615A1

  公开（公告）日：1996-10-10

  (EN) Processes using 2-deoxyribose-5-phosphate aldolase (DERA) are described for the preparation of 2-deoxyfucose and related compounds. In one embodiment, DERA is used to catalyse the condensation of acetaldehyde as donor and a 2(R)-hydroxy-3-(hydroxy or mercapto)-propionaldehyde derivative to form a 2-deoxysugar whose hydroxyls have the configuration of fucose. In another embodiment, DERA is used to catalyze the condensation of two moles of acetaldehyde as donor and one mole of a 2-substituted acetaldehyde acceptor to form a 2,4,6-trideoxyhexose via a 4-substituted-3-hydroxybutanal intermediate.(FR) Procédés utilisant la 2-désoxyribose-5-phosphatealdolase (DERA) pour la préparation de 2-désoxyfucose et de composés associés. Selon un mode de réalisation, la DERA est utilisée pour catalyser la condensation de l'acétaldéhyde comme donneur et d'un dérivé de 2(R)-hydroxy-3-(hydroxy ou mercapto)-propionaldéhyde pour former un sucre 2-désoxy dont les hydroxyles ont la configuration du fucose. Selon un autre mode de réalisation, la DERA est utilisée pour catalyser la condensation de deux moles d'acétaldéhyde comme donneur et d'une mole d'un accepteur acétaldéhyde substitué en position 2 de façon à former un 2,4,6-tridésoxyhexose via un intermédiaire 4-substitué-3-hydroxybutanal.

  (ZH) 描述了使用2-脱氧核糖-5-磷酸醛缩酶（DERA）制备2-脱氧岩藻糖和相关化合物的过程。在一种实施方式中，DERA用于催化乙醛作为供体和2（R）-羟基-3-（羟基或巯基）-丙醛衍生物的缩合，形成一个2-去氧糖，其羟基具有岩藻糖的构型。在另一种实施方式中，DERA用于催化两摩尔乙醛作为供体和一摩尔2-取代乙醛受体的缩合，通过4-取代-3-羟基丁醛中间体形成一个2,4,6-三去氧己糖。
• Rhodomycin-group of antibiotics and process for preparing same
  申请人：SANRAKU-OCEAN CO., LTD.

  公开号：EP0022574A1

  公开（公告）日：1981-01-21

  New anthracycline glycoside derivatives RDC havinc botent anticancer activities and lower toxicities and a process for the production thereof by microbiological Glycosidation of ε-rhodomycinone ε-isorhodomycinone β-rhodomycinone τ-rhodomycinone β-pyrromycinone using Streptomyces Galilaeus having the general formula I: wherein a substitution of R1, R2, R3 and R4 represents a ,carbomethoxy or hydroxyl group, ,hydroxyl hydroxyl group, and a hydrogen atom, respectively. group and hydroxyl group, or hydroxyl group, carbomethoxy group and hydroxyl group,

  新的蒽环类糖苷衍生物 RDC havinc botent anticancer activities and lower toxicities and a process for production thereof by microbiological Glycosidation of ε-rhodomycinone ε-isorhodomycinone β-rhodomycinone τ-rhodomycinone β-pyrromycinone using Streptomyces Galilaeus having general formula I: 其中 R1、R2、R3 和 R4 的取代基分别代表羰基或羟基、羟基羟基和氢原子、