Ethanone, 1-(2,3-dichloro-4-methylphenyl)- | 1806274-48-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ethanone, 1-(2,3-dichloro-4-methylphenyl)-
• 英文别名: 1-(2,3-dichloro-4-methylphenyl)ethanone
• CAS: 1806274-48-5
• 化学式: C₉H₈Cl₂O
• 分子量: 203.06
• InChiKey: CNMSVJDGTNKCBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• p-Substituted Asymmetric Ureas and Medical Uses Thereof
  申请人：Helsinn Healthcare SA

  公开号：US20150252021A1

  公开（公告）日：2015-09-10

  Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula I: or pharmaceutically acceptable salts thereof.

  本文披露了一种通过ghrelin受体介导的病理生理机制预防和/或治疗疾病的化合物、组合物和方法。这些化合物具有一般的化学式I：或其药用盐。
• ASYMMETRIC UREAS AND MEDICAL USES THEREOF
  申请人：GARCIA RUBIO Silvina

  公开号：US20120220629A1

  公开（公告）日：2012-08-30

  Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I):

  本文披露了一种用于预防和/或治疗由胃饥饿素受体病理生理介导的疾病的化合物、组合物和方法。这些化合物具有一般式(I)。
• Process for producing antifungal pyridazinone derivatives and certain novel compounds produced by such a process
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0089650A1

  公开（公告）日：1983-09-28

  Compounds of formula (I): [wherein R' and R3 represent hydrogen or halogen atoms, R2 represents a hydrogen or halogen atom or a lower alkyl or alkoxy group (provided R', R2 and R3 are not simultaneously hydrogen), ...... represents a single or double carbon-carbon bond and, where it is a single bond, R4 represents a group of formula -SR5 (wherein R5 represents an optionally substituted alkyl, phenyl, aralkyl or pyridyl group or a lower alkenyl group) and, where it is a double bond, R4 represents hydrogen] can be prepared by reacting a compound of formula (II): with a compound of formula R6H [where R6 represents a group -SR5, a group -SR7 (where R7 represents a group of formula and Y represents oxygen or sulphur, R8 and R9 represent lower alkoxy groups and R10 represents a lower alkoxy, lower alkyl or phenyl group), a methoxy group or a halogen atom) to give a compound of formula (IV): or, where R6 represents a methoxy group, a methyl ester thereof; reacting this compound with hydrazine to give a compound of formula (V): or (VI): and if necessary, treating the compound of formula (V) with an acid or a base to produce the compound of formula (VI). All of the compounds of formula (I) are valuable antifungal agents and compounds of formula (V) where R6 represents a group of formula -SR5 are novel compounds.

  式(I)化合物： 其中 R' 和 R3 代表氢原子或卤素原子，R2 代表氢原子或卤素原子或低级烷基或烷氧基（条件是 R'、R2 和 R3 不同时为氢），...... 代表单碳碳键或双碳碳键，如果是单键，R4 代表式-SR5 的基团（其中 R5 代表任选取代的烷基、苯基、芳烷基或吡啶基或低级烯基），如果是双键，R4 代表氢]可通过式（II）化合物与式 R6H[其中 R6 代表基团-SR5、基团-SR7（其中 R7 代表基团-SR7）、基团-R6H]反应制备： 与式 R6H[其中 R6 代表一个基团-SR5、一个基团-SR7（其中 R7 代表一个式基团 和 Y 代表氧或硫，R8 和 R9 代表低级烷氧基，R10 代表低级烷氧基、低级烷基或苯基）、甲氧基或卤原子)，得到式(IV)化合物： 或（其中 R6 代表甲氧基）其甲酯；将该化合物与肼反应，得到式（V）化合物： 或 (VI)： 必要时，用酸或碱处理式（V）化合物，生成式（VI）化合物。所有式（I）化合物都是有价值的抗真菌剂，而式（V）化合物（其中 R6 代表式-SR5 的基团）则是新型化合物。
• Chirale Glucoside und deren Verwendung als chirale Dotierstoffe zur Herstellung von cholestrisch-flüssigkristallinen Zusammensetzungen
  申请人：BASF Aktiengesellschaft

  公开号：EP1092721B1

  公开（公告）日：2007-12-19
• SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF
  申请人：HELSINN HEALTHCARE SA

  公开号：US20170145038A1

  公开（公告）日：2017-05-25

  Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general Formula I: or pharmaceutically acceptable salts thereof.