p-tert.-Butylpivalophenon | 62705-59-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-tert.-Butylpivalophenon
• 英文别名: 1-(3-tert-Butylphenyl)-2,2-dimethylpropan-1-one
• CAS: 62705-59-3
• 化学式: C₁₅H₂₂O
• 分子量: 218.339
• InChiKey: ZCLUZOFJDNRKHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Isoprenyl Compounds and Methods Thereof
  申请人：Stock Jeffry B.

  公开号：US20100184768A1

  公开（公告）日：2010-07-22

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他事项外，本发明提供了新型异戊二烯基化合物，能够有效调节炎症反应，并提供包含这些异戊二烯基化合物的药物、化妆品、化妆品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或症状。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或症状。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或症状以及用于治疗或预防与抑制炎症反应相关的疾病或症状的方法。
• PROTEASE INHIBITORS
  申请人：Mutz Mitchell W.

  公开号：US20120041019A1

  公开（公告）日：2012-02-16

  Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing the proliferation of HIV.

  本发明提供了一些有用的蛋白酶抑制剂化合物，以及使用和制备这些化合物的方法和含有这些化合物的组合物。在一种实施方式中，这些化合物可用于抑制HIV蛋白酶酶，因此可用于减缓HIV的增殖。
• POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
  申请人：Brown Jason W.

  公开号：US20120094992A1

  公开（公告）日：2012-04-19

  Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.

  以下式子的化合物被提供用于抑制Poly (ADP-ribose) Polymerase (PARP)的作用： 其中变量在此定义。还提供了制备该化合物的药物组合物、工具箱和制造品、中间体的方法以及使用该化合物的方法。
• ISOPRENYL COMPOUNDS AND METHODS THEREOF
  申请人：Stock Jeffry B.

  公开号：US20130310559A1

  公开（公告）日：2013-11-21

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  本发明提供了新型异戊烯基化合物，能够有效调节炎症反应，并且包括这些异戊烯基化合物的制药、化妆品、护肤品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症以及用于治疗或预防与抑制炎症反应相关的疾病或病症的方法。
• Isoprenyl compounds and methods thereof
  申请人：Signum Biosciences, Inc.

  公开号：US10314802B2

  公开（公告）日：2019-06-11

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他外，本发明提供了能够有效调节炎症反应的新型异戊烯基化合物，以及包含这些异戊烯基化合物的药物、化妆品、药妆和外用组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎化合物可用于治疗或预防与抑制炎症反应有关的疾病或病症。因此，本发明还提供了治疗或预防与炎症有关的疾病或病症的方法，以及治疗或预防与抑制炎症反应有关的疾病或病症的方法。