2-(2-hydroxyacetoxy)propionic acid | 136532-17-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-hydroxyacetoxy)propionic acid
• 英文别名: 2-(2-Hydroxyacetyl)oxypropanoic acid
• CAS: 136532-17-7
• 化学式: C₅H₈O₅
• mdl: MFCD19231477
• 分子量: 148.116
• InChiKey: HKVBZVITUCIVRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxyacetoxy)propionic acid 在 三聚氯氰 、 三乙胺 作用下， 以 丙酮 为溶剂， 以72%的产率得到3-甲基-1,4-二噁烷-2,5-二酮
  参考文献：
  名称：

  功能化双内酯作为合成聚（α-羟基）酸单体的通用途径

  摘要：

  描述了在结构上类似于丙交酯的功能化六元双内酯的合成途径。通过使用正交保护基团，通过氰尿酰氯介导的相应线性α-羟基酸二聚体的环化，以直接的方式合成官能化双内酯。三种不同的双内酯 - 甲基乙交酯、苄氧基甲基乙交酯和 2-苄氧基甲基-5-甲基乙交酯 - 通过相同的程序合成证明了该路线的多功能性。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

  DOI：

  10.1002/ejoc.200300181
• 作为产物：
  描述：

  benzyl 2-[2-(tert-butyldimethylsilanyloxy)acetoxy]propionate 在 palladium on activated charcoal 四丁基氟化铵 、 氢气 、 溶剂黄146 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 3.0h， 生成 2-(2-hydroxyacetoxy)propionic acid
  参考文献：
  名称：

  功能化双内酯作为合成聚（α-羟基）酸单体的通用途径

  摘要：

  描述了在结构上类似于丙交酯的功能化六元双内酯的合成途径。通过使用正交保护基团，通过氰尿酰氯介导的相应线性α-羟基酸二聚体的环化，以直接的方式合成官能化双内酯。三种不同的双内酯 - 甲基乙交酯、苄氧基甲基乙交酯和 2-苄氧基甲基-5-甲基乙交酯 - 通过相同的程序合成证明了该路线的多功能性。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

  DOI：

  10.1002/ejoc.200300181
• 作为试剂：
  描述：

  甘油 、 水 在 2-(2-hydroxyacetoxy)propionic acid 作用下， 生成 2-(2-hydroxyacetoxy)propionic acid
  参考文献：
  名称：

  pH-sensitive nanoparticles for oral insulin delivery

  摘要：

  本发明揭示了由pH敏感聚合物、疏水材料、内部稳定剂、外部稳定剂和胰岛素药物组成的pH敏感纳米颗粒。本发明还包括一种制备pH敏感纳米颗粒的方法，特别是多重乳液溶剂蒸发法。本发明的pH敏感纳米颗粒具有100-300纳米的粒径和良好的pH敏感性能。在链脲佐菌素（STZ）诱导的糖尿病大鼠中观察到明显的血糖水平下降，并且在口服胰岛素负载的pH敏感纳米颗粒后，胰岛素的生物利用度超过10％。

  公开号：

  US08859004B2

文献信息

• Composite Materials Based On Polysilicic Acid And Method For The Production Thereof
  申请人：Teller Marianne

  公开号：US20070196419A1

  公开（公告）日：2007-08-23

  The invention relates to composite materials based on polysilicic acid, said materials containing novel compositions which have improved material properties and can be in the form of dispersions, pastes, powders, granulated materials, layers or compact moulded bodies. The aim of the invention is to produce composite materials based on polysilicic acid with improved mechanical properties. To this end, the composite materials contain polysilicic acid, between 0.01 and 20 mass % of an organic polymer, more than 15 mass % of at least one calcium phosphate phase, and optionally a use-specific additive. The material produced according to the invention can be implanted or injected. The composition of the composite material with the resulting properties enables the composite material to be used for bone substitution and/or bone regeneration in both human medicine and animal medicine. The inventive material can also be used to heal wounds.

  本发明涉及基于多硅酸的复合材料，该材料含有具有改进材料性质的新型组分，可以呈现为分散体、浆糊、粉末、颗粒材料、层或紧凑成型体。本发明的目的是生产基于多硅酸的复合材料，具有改进的机械性能。为此，复合材料含有多硅酸、0.01至20质量％的有机聚合物、超过15质量％的至少一种磷酸钙相，以及可选的用途特定添加剂。根据本发明制备的材料可以植入或注射。复合材料的组成和所得性能使得该复合材料可用于人类医学和动物医学中的骨替代和/或骨再生。本发明材料还可用于愈合伤口。
• pH-SENSITIVE NANOPARTICLES FOR ORAL INSULIN DELIVERY
  申请人：ZHANG Lijuan

  公开号：US20130034589A1

  公开（公告）日：2013-02-07

  The present invention discloses the pH-sensitive nanoparticles composed of pH-sensitive polymer, hydrophobic material, internal stabilizer, external stabilizer content and insulin drug. The present invention also includes a method for preparation of pH-sensitive nanoparticles, in particular, a multiple emulsions solvent evaporation method. The pH-sensitive nanoparticles of the present invention show good pH-sensitive property with 100-300 nanometer particle size. Significant decrease in blood glucose level is observed in streptozotocin (STZ)-induced diabetic rats and the bioavailability of insulin is more than 10% after oral administration of the insulin-loaded pH-sensitive nanoparticles.

  本发明揭示了由pH敏感聚合物、疏水材料、内部稳定剂、外部稳定剂和胰岛素药物组成的pH敏感纳米粒子。本发明还包括一种制备pH敏感纳米粒子的方法，特别是一种多重乳液溶剂蒸发法。本发明的pH敏感纳米粒子具有100-300纳米的粒径和良好的pH敏感性能。在链脲佐菌素（STZ）诱导的糖尿病大鼠中观察到明显的血糖水平下降，并且口服胰岛素负载的pH敏感纳米粒子的生物利用度超过10％。
• New Insights into Poly(lactic-<i>co</i>-glycolic acid) Microstructure: Using Repeating Sequence Copolymers To Decipher Complex NMR and Thermal Behavior
  作者：Ryan M. Stayshich、Tara Y. Meyer

  DOI：10.1021/ja102670n

  日期：2010.8.11

  Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range M-n = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the H-1 and C-13 NMR spectra, the diastereotopic methylene resonances in the H-1 NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.