(R)-3-methoxy-2,2-dimethyl-3,6-dihydro-(2H)-pyran | 1005773-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (R)-3-methoxy-2,2-dimethyl-3,6-dihydro-(2H)-pyran
• 英文别名: (5R)-5-methoxy-6,6-dimethyl-2,5-dihydropyran
• CAS: 1005773-92-1
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: NJIMKUDEOUBSKB-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-3-methoxy-2,2-dimethyl-3,6-dihydro-(2H)-pyran 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以65%的产率得到(R)-5-methoxy-6,6-dimethyl-5,6-dihydropyran-2-one
  参考文献：
  名称：

  Alternative and Expedient Asymmetric Syntheses of l-(+)-Noviose

  摘要：

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.

  DOI：

  10.1021/ol702655c
• 作为产物：
  描述：

  (R)-5-allyloxy-4-methoxy-5-methylhex-2-ene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以87%的产率得到(R)-3-methoxy-2,2-dimethyl-3,6-dihydro-(2H)-pyran
  参考文献：
  名称：

  Alternative and Expedient Asymmetric Syntheses of l-(+)-Noviose

  摘要：

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.

  DOI：

  10.1021/ol702655c

文献信息

• Alternative and Expedient Asymmetric Syntheses of <scp>l</scp>-(+)-Noviose
  作者：Stephen Hanessian、Luciana Auzzas

  DOI：10.1021/ol702655c

  日期：2008.1.1

  L-(+)-Noviose, the sugar component of the antibiotic novobiocin, was synthesized from readily available non-carbohydrate starting materials relying on stoichiometric and asymmetric processes by two independent methods, comprising six and nine steps, in 27 and 20% overall yields, respectively.