azithromycin dihydrochloride | 90581-30-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: azithromycin dihydrochloride
• 英文别名: Azithromycin monohydrochloride；(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;hydrochloride
• CAS: 90581-30-9
• 化学式: C₃₈H₇₂N₂O₁₂*2ClH
• 分子量: 821.918
• InChiKey: RNIHVUHXAKFKSV-WVVFQGGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.32
• 重原子数：
  53
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  180
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• Sustained release compositions using wax-like materials
  申请人：Chen Andrew Xian

  公开号：US10888521B2

  公开（公告）日：2021-01-12

  Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising the pellets and methods for preparing and using such pellets and dosage forms are also provided.

  本发明提供了由 (a) 活性成分 (b) 蜡样制剂和 (c) 球化剂组成的缓释球形或非球形颗粒。还提供了包含这些颗粒的口服剂型以及制备和使用这些颗粒和剂型的方法。
• SUSTAINED RELEASE PELLETS COMPRISING WAX-LIKE MATERIAL
  申请人：Farnam Companies, Inc.

  公开号：EP2144599A2

  公开（公告）日：2010-01-20
• SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS
  申请人：Chen Andrew Xian

  公开号：US20080220079A1

  公开（公告）日：2008-09-11

  Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets and methods for preparing and using such pellets and dosage forms are also provided.
• [EN] METHOD FOR TREATMENT AND PREVENTION OF ACUTE AND CHRONIC PSEUDOMONAS AERUGINOSA AIRWAY INFECTIONS WITH INHALABLE MACROLIDES<br/>[FR] PROCEDE DE TRAITEMENT ET DE PREVENTION DES INFECTIONS AIGUES ET CHRONIQUES DES VOIES AERIENNES PAR PSEUDOMONAS AERUGINOSA AU MOYEN DE MACROLIDES POUVANT ETRE INHALES
  申请人：ANBICS PATENTS LICENCES AG

  公开号：WO2004075874A1

  公开（公告）日：2004-09-10

  Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhala­tion. The mechanism of action is the inhibition of the quo­rum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodo­1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lac­tone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.
• [EN] SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS<br/>[FR] COMPOSITIONS À LIBÉRATION PROLONGÉE UTILISANT DES MATIÈRES CIREUSES
  申请人：FARNAM CO INC

  公开号：WO2008109462A2

  公开（公告）日：2008-09-12

  [EN] Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets and methods for preparing and using such pellets and dosage forms are also provided.
  [FR] L'invention concerne des granules sphériques ou non sphériques à libération prolongée qui comprennent (a) un principe actif, (b) un agent cireux et (c) un agent de sphéronisation. Elle concerne aussi des formes pharmaceutiques orales comprenant lesdits granules, et des procédés de préparation et d'utilisation de ces granules et formes pharmaceutiques.