(2R,3S)-2,3-dimethylpentan-1-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S)-2,3-dimethylpentan-1-ol
• 化学式: C₇H₁₆O
• 分子量: 116.2
• InChiKey: MIBBFRQOCRYDDB-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• TOLL LIKE RECEPTOR MODULATOR COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20160289229A1

  公开（公告）日：2016-10-06

  The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

  本公开涉及调节类似受体调节剂化合物，例如二氨基吡啶并[3,2 D]嘧啶化合物和药物组合物，其中调节类似受体（例如TLR-8），以及制备和使用它们的方法。
• Molecules which Bind to the Dimerization Initiation Site (DIS) of HIV RNA, Their Synthesis and Their Applications as Drugs
  申请人：Pale Patrick

  公开号：US20110118202A1

  公开（公告）日：2011-05-19

  The dimerization of HIV RNA is a key step in the virus replication cycle. Based on RNA DIS crystal structures, a novel kind of compounds, dimeric or not, based on neamine was designed and synthesized. Biological studies showed that such compounds bind and interfere with the targeted RNA sequence, opening a new anti-HIV approach. The crystal structures and bio-chemical experiments showed that the DIS of HIV-1 genomic RNA is a target for new anti-HIV drugs and that those drugs could be derived from aminoglycosides. The results revealed that binding of aminoglycosides to the DIS is specific regarding both the aminoglycoside family and the RNA subtype.
• MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV
  申请人：Gilead Sciences, Inc.

  公开号：US20170071944A1

  公开（公告）日：2017-03-16

  Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
• US9670205B2
  申请人：——

  公开号：US9670205B2

  公开（公告）日：2017-06-06
• [EN] MODULATORS OF TOLL-LIKE RECPTORS FOR THE TREATMENT OF HIV<br/>[FR] MODULATEURS DE RÉCEPTEURS DE TYPE TOLL POUR LE TRAITEMENT DU VIH
  申请人：GILEAD SCIENCES INC

  公开号：WO2017048727A1

  公开（公告）日：2017-03-23

  Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.