2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,4-dihydropyrazole-3-carboxamide;hydrochloride | 1078736-19-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,4-dihydropyrazole-3-carboxamide;hydrochloride
• CAS: 1078736-19-2
• 化学式: C₁₄H₁₅F₃N₄O₂*ClH
• 分子量: 364.755
• InChiKey: MMSMHPPOKWNNCT-CFKUEIMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.86
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (R)-[3-(5-carbamoyl-4,5-dihydropyrazol-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 在 盐酸 作用下， 以 1,4-二氧六环 、 乙酸乙酯 为溶剂， 反应 12.0h， 以74%的产率得到2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,4-dihydropyrazole-3-carboxamide;hydrochloride
  参考文献：
  名称：

  Synthesis and biological evaluation of pyrazoline analogues with β-amino acyl group as dipeptidyl peptidase IV inhibitors

  摘要：

  A series of pyrazoline derivatives with beta-amino acyl group were synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV. Several pyrazoline derivatives exhibited submicromolar inhibitory activities against DPP-IV. X-ray co-crystal structure of initial hit compound 1h was determined. Among this series, carboxylic acid substituted pyrazoline derivative 2u was the most active and greatly decreased the inhibitory activity toward CYP3A4 enzyme. (C) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.11.029

文献信息

• Synthesis and biological evaluation of pyrazoline analogues with β-amino acyl group as dipeptidyl peptidase IV inhibitors
  作者：Mi Ae Jun、Woul Seong Park、Seung Kyu Kang、Ki Young Kim、Kwang Rok Kim、Sang Dal Rhee、Myung Ae Bae、Nam Sook Kang、Sang-Kwon Sohn、Sung Gyu Kim

  DOI：10.1016/j.ejmech.2007.11.029

  日期：2008.9

  A series of pyrazoline derivatives with beta-amino acyl group were synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV. Several pyrazoline derivatives exhibited submicromolar inhibitory activities against DPP-IV. X-ray co-crystal structure of initial hit compound 1h was determined. Among this series, carboxylic acid substituted pyrazoline derivative 2u was the most active and greatly decreased the inhibitory activity toward CYP3A4 enzyme. (C) 2007 Elsevier Masson SAS. All rights reserved.