(3R)-3-(trifluoromethyl)cyclohexan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R)-3-(trifluoromethyl)cyclohexan-1-one
• 化学式: C₇H₉F₃O
• 分子量: 166.14
• InChiKey: YHADNJOEQWBXAR-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHOD FOR PRODUCING (1R,3R)-3-(TRIFLUOROMETHYL)CYCLOHEXAN-1-OL AND INTERMEDIATE THEREOF
  申请人：API Corporation

  公开号：EP3922728A1

  公开（公告）日：2021-12-15

  The present invention aims to provide a novel method for industrially producing (1R,3R)-3-(trifluoromethyl)cyclohexan-1-ol and an intermediate thereof with high optical purity, high selectivity, and high efficiency at a low cost. The present invention provides a method for producing a compound represented by the formula (3) including bringing a carbon-carbon double bond reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell, and a carbonyl reductase, a microorganism or cell having an ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture solution containing the enzyme which is obtained by culturing the microorganism or cell into contact with a compound represented by the formula (1) to obtain a compound represented by the formula (3):

  本发明旨在提供一种工业化生产(1R,3R)-3-(三氟甲基)环己-1-醇及其中间体的新型方法，该方法具有高光学纯度、高选择性和高效率，且成本低廉。 本发明提供了一种生产由式（3）表示的化合物的方法，包括将碳碳双键还原酶、具有产生该酶能力的微生物或细胞、该微生物或细胞的加工产品和/或通过培养该微生物或细胞获得的含有该酶的培养液、和羰基还原酶、具有产生该酶能力的微生物或细胞、该微生物或细胞的加工产物和/或通过培养该微生物或细胞而获得的含有该酶的培养液与式(1)表示的化合物接触，以获得式(3)表示的化合物：