4-ethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-pyridin-6-one | 1073451-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-ethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-pyridin-6-one
• CAS: 1073451-84-9
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: WSIARYDSHGCOCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(4-methoxyphenylmethylidene)-2-nitrobenzenesulfonamide 在 potassium carbonate 、 苯硫酚 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 11.0h， 生成 4-ethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-pyridin-6-one
  参考文献：
  名称：

  A New Synthesis of Dihydropyridin-2-ones from Brassard’s Diene and Imines

  摘要：

  A new method for the synthesis of dihydropyridin-2-ones from various N-2-nitrobenzenesulfonyl (nosyl) imines and 1,3-diethoxy-1-trimethylsiloxy-1,3-butadiene (Brassard's diene) under weakly-basic conditions is described. This synthesis of dihydropyridin-2-ones involves the initial addition reaction of Brassard's diene to imines to afford the adducts followed by a cyclization reaction that forms the corresponding 4-ethoxy-5,6-dihydro-1H-pyridin-2-ones in moderate to good yields after deprotection of its nosyl group from the adducts.

  DOI：

  10.3987/com-08-s(n)51

文献信息

• A New Synthesis of Dihydropyridin-2-ones from Brassard’s Diene and Imines
  作者：Teruaki Mukaiyama、Yuji Maruyama、Takayuki Kitazawa

  DOI：10.3987/com-08-s(n)51

  日期：——

  A new method for the synthesis of dihydropyridin-2-ones from various N-2-nitrobenzenesulfonyl (nosyl) imines and 1,3-diethoxy-1-trimethylsiloxy-1,3-butadiene (Brassard's diene) under weakly-basic conditions is described. This synthesis of dihydropyridin-2-ones involves the initial addition reaction of Brassard's diene to imines to afford the adducts followed by a cyclization reaction that forms the corresponding 4-ethoxy-5,6-dihydro-1H-pyridin-2-ones in moderate to good yields after deprotection of its nosyl group from the adducts.