Iridium(3+);6-methoxyquinoline-8-thiolate | 36423-31-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Iridium(3+);6-methoxyquinoline-8-thiolate
• CAS: 36423-31-1
• 化学式: C₃₀H₂₄IrN₃O₃S₃
• 分子量: 762.957
• InChiKey: PNDMEJHJHRTYMA-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  6.45
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-methoxy-8-quinolinethiolate hydrochloride 、 ammonium hexachloroiridate(III) * H2O 以 乙醇 、 水 为溶剂， 反应 0.17h， 生成 Iridium(3+);6-methoxyquinoline-8-thiolate
  参考文献：
  名称：

  Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates

  摘要：

  It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.

  DOI：

  10.1007/s10593-008-0075-8

文献信息

• Synthesis and cytotoxicity of methyl-and methoxy-substituted metal 8-quinolinethiolates
  作者：E. Lukevics、D. Zaruma、J. Ashaks、I. Shestakova、I. Domracheva、A. Gulbe、V. Bridane

  DOI：10.1007/s10593-008-0075-8

  日期：2008.5

  It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity.