(4-Chlorophenyl)-[2-(4-methylanilino)-3-(4-methylphenyl)-5-phenylimidazol-4-yl]methanone | 1095593-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Chlorophenyl)-[2-(4-methylanilino)-3-(4-methylphenyl)-5-phenylimidazol-4-yl]methanone
• CAS: 1095593-41-1
• 化学式: C₃₀H₂₄ClN₃O
• 分子量: 477.993
• InChiKey: AKRKVMBOXIIHMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N'-[N,N'-bis(4-methylphenyl)carbamimidoyl]-N,N-diethylbenzenecarboximidamide 、 2'-溴-4-氯苯乙酮 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 以65%的产率得到(4-Chlorophenyl)-[2-(4-methylanilino)-3-(4-methylphenyl)-5-phenylimidazol-4-yl]methanone
  参考文献：
  名称：

  A facile synthesis of structurally novel 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from amidinothioureas

  摘要：

  We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl bromides under mild conditions to afford the corresponding diversely functionalized imidazoles 3 in moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.10.012

文献信息

• A facile synthesis of structurally novel 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from amidinothioureas
  作者：Jitendra C. Kaila、Arshi B. Baraiya、Kamala K. Vasu、V. Sudarsanam

  DOI：10.1016/j.tetlet.2008.10.012

  日期：2008.12

  We report here a convenient and efficient two-step synthesis of 1-aryl-2-arylamino-4-alkyl/phenyl-5-aroyl-1H-imidazoles from easily available amidinothioureas. Guanylation of amidinothioureas 1 using mercury(II) chloride as a thiophile yielded amidinoguanidines 2, which reacted with various phenacyl bromides under mild conditions to afford the corresponding diversely functionalized imidazoles 3 in moderate to good yields. (C) 2008 Elsevier Ltd. All rights reserved.