N-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine | 1130118-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine
• 英文别名: 1-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-1-methylhydrazine；2-[5-[Amino(methyl)amino]tetrazol-1-yl]ethanol
• CAS: 1130118-90-9
• 化学式: C₄H₁₀N₆O
• 分子量: 158.163
• InChiKey: USHPXFVHGSVQIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine 在 溴 、 溶剂黄146 作用下， 以 水 为溶剂， 以0.13 g的产率得到1,4-bis[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-1,4-dimethyl-2-tetrazene
  参考文献：
  名称：

  Synthesis of Functionalized Tetrazenes as Energetic Compounds

  摘要：

  1,4-Bis[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-1,4-dimethyl-2-tetrazene (12a), 1,4-bis[1-isopropoxycarbonyiniethyl-1H-tetrazol-5-yl]-1,4-dimethyl-2-tetrazene (12b), and 1,4-bis[1-carboxymethyl-1H-tetrazol-5yl]-1,4-dimethyl-2-tetrazene (13) have been synthesized as new nitrogen-rich compounds. The tetrazenes were obtained by oxidation of the corresponding tetrazolylhydrazines using bromine. Moreover, a new method to prepare tetrazolylhydrazines in high yield using 5-bromotetrazoles has been developed. 12a, 12b, and 13 were characterized using vibrational spectroscopy (IR, Raman), mass spectrometry, and multinuclear NMR spectroscopy. The crystal structures of 12a, 12b, and 13 were determined using single crystal X-ray diffraction. Furthermore, the energetic properties of 12a, 12b, and 13 have been investigated using DSC and bomb calorimetric measurements. The sensitivity data toward impact and friction has been determined using BAM methods.

  DOI：

  10.1021/jo802738c
• 作为产物：
  描述：

  N-[1-(2-acetoxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine 在 氢氧化钾 作用下， 以 水 为溶剂， 反应 1.0h， 以59%的产率得到N-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine
  参考文献：
  名称：

  作为聚合物前体的N-[1-(2-羟乙基)-1H-四唑-5-基]-N-甲基肼的合成

  摘要：

  富氮聚合物由六亚甲基二异氰酸酯和 N-[1-(2-羟乙基)-1H-四唑-5-基]-N-甲基肼 (3) 单体反应形成。通过用叠氮化钠对 4-[2-(乙酰氧基)乙基]-2-甲基氨基硫脲 (10) 的甲基化硫原子进行亲核取代和最终脱保护形成的 N-[1-2-(乙酰氧基乙基) 合成化合物 3 -1H-四唑-5-基]-N-甲基肼(13)。此外，合成了异构体4-(2-叠氮基乙基)-2-甲基氨基脲(18)至3。化合物 3、10、13 和 4-[2-(三甲基甲硅烷氧基)乙基]-2-甲基氨基硫脲 (15) 通过使用振动光谱 (IR、拉曼)、质谱和多核 NMR 光谱进行表征。通过使用单晶X射线衍射确定了3、10和13的晶体结构。聚合物的分子量由 GPC 测定。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  DOI：

  10.1002/ejoc.200800764

文献信息

• Synthesis of<i>N</i>-[1-(2-Hydroxyethyl)-1<i>H</i>-tetrazol-5-yl]-<i>N</i>-methylhydrazine as Polymeric Precursor
  作者：Klaus Banert、Thomas M. Klapötke、Stefan M. Sproll

  DOI：10.1002/ejoc.200800764

  日期：2009.1

  nitrogen-rich polymer was formed from the reaction of hexamethylene diisocyanate and N-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine (3) monomers. Compound 3 was synthesized by a nucleophilic substitution of the methylated sulfur atom of 4-[2-(acetoxy)ethyl]-2-methylthiosemicarbazide (10) with sodium azide and final deprotection of the formed N-[1-2-(acetoxyethyl)-1H-tetrazol-5-yl]-N-methylhydrazine

  富氮聚合物由六亚甲基二异氰酸酯和 N-[1-(2-羟乙基)-1H-四唑-5-基]-N-甲基肼 (3) 单体反应形成。通过用叠氮化钠对 4-[2-(乙酰氧基)乙基]-2-甲基氨基硫脲 (10) 的甲基化硫原子进行亲核取代和最终脱保护形成的 N-[1-2-(乙酰氧基乙基) 合成化合物 3 -1H-四唑-5-基]-N-甲基肼(13)。此外，合成了异构体4-(2-叠氮基乙基)-2-甲基氨基脲(18)至3。化合物 3、10、13 和 4-[2-(三甲基甲硅烷氧基)乙基]-2-甲基氨基硫脲 (15) 通过使用振动光谱 (IR、拉曼)、质谱和多核 NMR 光谱进行表征。通过使用单晶X射线衍射确定了3、10和13的晶体结构。聚合物的分子量由 GPC 测定。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
• Synthesis of Functionalized Tetrazenes as Energetic Compounds
  作者：Johannes Heppekausen、Thomas M. Klapötke、Stefan M. Sproll

  DOI：10.1021/jo802738c

  日期：2009.3.20

  1,4-Bis[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]-1,4-dimethyl-2-tetrazene (12a), 1,4-bis[1-isopropoxycarbonyiniethyl-1H-tetrazol-5-yl]-1,4-dimethyl-2-tetrazene (12b), and 1,4-bis[1-carboxymethyl-1H-tetrazol-5yl]-1,4-dimethyl-2-tetrazene (13) have been synthesized as new nitrogen-rich compounds. The tetrazenes were obtained by oxidation of the corresponding tetrazolylhydrazines using bromine. Moreover, a new method to prepare tetrazolylhydrazines in high yield using 5-bromotetrazoles has been developed. 12a, 12b, and 13 were characterized using vibrational spectroscopy (IR, Raman), mass spectrometry, and multinuclear NMR spectroscopy. The crystal structures of 12a, 12b, and 13 were determined using single crystal X-ray diffraction. Furthermore, the energetic properties of 12a, 12b, and 13 have been investigated using DSC and bomb calorimetric measurements. The sensitivity data toward impact and friction has been determined using BAM methods.