N-(furan-2-ylmethyl)-1,4,6-trimethylpyrazolo[3,4-b]pyridine-3-sulfonamide | 1159275-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: N-(furan-2-ylmethyl)-1,4,6-trimethylpyrazolo[3,4-b]pyridine-3-sulfonamide
• CAS: 1159275-08-7
• 化学式: C₁₄H₁₆N₄O₃S
• 分子量: 320.372
• InChiKey: ASIOCAWVKIPODD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  98.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-呋喃甲胺 、 1H-Pyrazolo[3,4-b]pyridine-3-sulfonoyl chloride, 1,4,6-trimethyl- 在 三乙胺 作用下， 以 苯 为溶剂， 以64%的产率得到N-(furan-2-ylmethyl)-1,4,6-trimethylpyrazolo[3,4-b]pyridine-3-sulfonamide
  参考文献：
  名称：

  Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides

  摘要：

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.

  DOI：

  10.1007/s10593-009-0169-y

文献信息

• Synthesis and transformations of substituted 4,6-dimethylpyrazolo[3,4-b]pyridyl-3-azides and -sulfonyl chlorides
  作者：I. G. Dmitrieva、L. V. Dyadyuchenko、V. D. Strelkov、E. A. Kaigorodova

  DOI：10.1007/s10593-009-0169-y

  日期：2008.10

  Diazotization of the amino group of 3-amino-4,6-dimethylpyrazolo[3,4-b]pyrimidines and subsequent replacement of the diazo group in the formed diazonium chlorides by an azide group gave the corresponding 3-azido derivatives. Their reactions with active methylene compounds have been studied. Substitution of the diazo group by a sulfo group gave the related 4,6-dimethylpyrazolo-[3,4-b]pyridyl-3-sulfonyl chlorides and sulfonylamides.