N-(2,2-dimethoxyethyl)glycine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2,2-dimethoxyethyl)glycine
• 英文别名: 2,2-Dimethoxyethyl glycine；2-(2,2-dimethoxyethylamino)acetic acid
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: AABKPXLCESPISO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氰胺 、 N-(2,2-dimethoxyethyl)glycine 以50%的产率得到N-amidino-N-(2,2-dimethoxyethyl)glycine
  参考文献：
  名称：

  Carbon-13 nuclear magnetic resonance studies of creatine, creatinine and some of their analogs

  摘要：

  AbstractCreatine (N‐methyl‐N‐amidinoglycine), creatinine (1‐methyl‐2‐aminoimidazolin‐4‐one) and a series of 38 of their close structural analogs have been examined using natural abundance 13C NMR spectroscopy at 25.16 MHz. Both proton‐coupled and proton noise‐decoupled spectra were recorded. Unequivocal assignments of the carbon resonances could be made in the vast majority of cases. Both 13C NMR chemical shifts and 1J(CH) values can be used to characterize and to differentiate readily between analogs of creatine and analogs of creatinine. For example, the 1J(CH) coupling constants for the α‐carbons of the acyclic creatine analogs were all in the 140–142 Hz range, whereas the corresponding coupling constants for the related, cyclized creatinine analogs were all in the 150–152 Hz range.

  DOI：

  10.1002/mrc.1270130202
• 作为产物：
  描述：

  2,2-dimethoxyethyl N-benzyloxycarbonylglycine 在 钯 氢气 、 乙酸乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以to give 38 (180 mg, 77%)的产率得到N-(2,2-dimethoxyethyl)glycine
  参考文献：
  名称：

  Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections

  摘要：

  本发明涉及磷酸化利福霉素及其制备和使用方法。这些化合物可用作抗生素，用于预防和/或治疗骨和关节感染，特别是用于预防和/或治疗骨髓炎。

  公开号：

  US08524691B2

文献信息

• PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
  申请人：Dietrich Evelyne

  公开号：US20110178001A1

  公开（公告）日：2011-07-21

  The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.

  本发明涉及磷酸化利福霉素，以及制备和使用这些化合物的方法。这些化合物可用作抗生素，用于预防和/或治疗骨骼和关节感染，特别是用于预防和/或治疗骨髓炎。
• 2-Piperazinone compounds and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0643072A1

  公开（公告）日：1995-03-15

  Compounds of the formula [wherein A represents amidino group or an optionally substituted aminoethyl; R¹⁰ represents one species selected from a group consisting of nitro group, a halogen atom, a lower alkenyl group, a lower alkynyl group, a lower alkyloxycarbonyl group and a group represented by the formula OR¹¹ (wherein R¹¹ is hydrogen atom or a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group or a methanesulfonyl group, each of which may be substituted; R¹² and R¹³ respectively represent hydrogen atom, hydroxyl group, a lower alkoxy group or a halogen atom; X represents hydroxyl group, p-hydroxyphenyl group or an optionally esterified or amidated carboxyl group; Y represents an optionally esterified or amidated carboxyl group; and n denotes 1 or 2], or a salt thereof and agent for inhibiting adhesion of cells, which comprise said compound, and these have more potent and long lasting activities of inhibiting cell-adhesion, thus being useful as an orally administrable anti-thrombotic agent.

  式中的化合物 [其中 A 代表脒基或任选取代的氨基乙基；R¹⁰ 代表一种选自硝基、卤素原子、低级烯基、低级炔基、低级烷氧羰基和式 OR¹¹ 所代表的基团（其中 R¹¹ 为氢原子或低级烷基、低级烯基、低级炔基、低级烷酰基、氨基甲酰基或甲磺酰基，每个基团均可被取代；R¹² 和 R¹³ 分别代表氢原子、羟基、低级烷氧基或卤原子；X 代表羟基、对羟基苯基或任选酯化或酰胺化的羧基；Y 代表任选酯化或酰胺化的羧基；和 n 表示 1 或 2]，或其盐和抑制细胞粘附的制剂，其中包括所述化合物，这些化合物具有更强和更持久的抑制细胞粘附的活性，因此可用作口服抗血栓形成剂。
• US5550131A
  申请人：——

  公开号：US5550131A

  公开（公告）日：1996-08-27
• US8524691B2
  申请人：——

  公开号：US8524691B2

  公开（公告）日：2013-09-03
• [EN] PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS<br/>[FR] RIFAMYCINES PHOSPHONÉES ET LEURS UTILISATIONS POUR LA PRÉVENTION ET LE TRAITEMENT D'INFECTIONS DES OS ET DES ARTICULATIONS
  申请人：DIETRICH EVELYNE

  公开号：WO2010019511A2

  公开（公告）日：2010-02-18

  The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and joint infections, especially for the prophylaxis and/or treatment of osteomyelitis.