5-benzyl-2-decylamino-4-methylthiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-benzyl-2-decylamino-4-methylthiazole
• 英文别名: 5-benzyl-N-decyl-4-methyl-1,3-thiazol-2-amine
• 化学式: C₂₁H₃₂N₂S
• 分子量: 344.564
• InChiKey: AAWDKBSJWKRMLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-benzyl-3-bromopentane-2,4-dione 、 1-氨基癸烷 、 potassium thioacyanate 在 Na₂CO₃ on SiO₂ 、 NH₄OAc on Al₂O₃ 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以51%的产率得到5-benzyl-2-decylamino-4-methylthiazole
  参考文献：
  名称：

  Novel one-pot three-step reaction using supported reagents system: synthesis of 2-aminothiazoles

  摘要：

  One-pot tandem three-step reaction has been developed by using supported reagents system. The synthesis of 2-aminothiazoles was selected for confirming the effectiveness of the method using supported reagents system. One-pot three-step reaction effectively proceeded, and the yield of the products is higher than that in step-wise process. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.09.017

文献信息

• Novel one-pot three-step reaction using supported reagents system: synthesis of 2-aminothiazoles
  作者：Tadashi Aoyama、Sumiko Murata、Toshio Takido、Mitsuo Kodomari

  DOI：10.1016/j.tet.2007.09.017

  日期：2007.11

  One-pot tandem three-step reaction has been developed by using supported reagents system. The synthesis of 2-aminothiazoles was selected for confirming the effectiveness of the method using supported reagents system. One-pot three-step reaction effectively proceeded, and the yield of the products is higher than that in step-wise process. (c) 2007 Elsevier Ltd. All rights reserved.