4-(((4-cyclohexylphenyl)amino)methyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(((4-cyclohexylphenyl)amino)methyl)phenol
• 英文别名: 4-[(4-Cyclohexylanilino)methyl]phenol；4-[(4-cyclohexylanilino)methyl]phenol
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: ABONTKRUZYTIRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己基苯 在 palladium 10% on activated carbon 、 氢气 、 硝酸 作用下， 以 甲醇 、 乙醇 、 溶剂黄146 为溶剂， 反应 6.17h， 生成 4-(((4-cyclohexylphenyl)amino)methyl)phenol
  参考文献：
  名称：

  Structure–activity relationship study of E6 as a novel necroptosis inducer

  摘要：

  Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.04.038

文献信息

• Structure–activity relationship study of E6 as a novel necroptosis inducer
  作者：Jianfeng Mou、Ann Park、Yu Cai、Junying Yuan、Chengye Yuan

  DOI：10.1016/j.bmcl.2015.04.038

  日期：2015.8

  Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (5h and 5j) that can be used for further optimization studies as well as mechanism of action investigations. (C) 2015 Elsevier Ltd. All rights reserved.