(E)-N-(2-chloro-5-thiazolylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-N-(2-chloro-5-thiazolylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine
• 英文别名: 1-[N-(2-chloro-5-thiazolylmethyl)-N-ethylamino]-1-methylamino-2-nitroethylene；(E)-1-N'-[(2-chloro-1,3-thiazol-5-yl)methyl]-1-N'-ethyl-1-N-methyl-2-nitroethene-1,1-diamine
• 化学式: C₉H₁₃ClN₄O₂S
• 分子量: 276.747
• InChiKey: ADCNCRGCZHWZAS-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,1,1-三氯-2-硝基乙烷 、 (2-氯-噻唑-5-甲基)-乙基-胺 、 甲胺 在 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 3.0h， 以88%的产率得到(E)-N-(2-chloro-5-thiazolylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine
  参考文献：
  名称：

  噻唑基新烟碱化合物及其制备方法和应用

  摘要：

  本发明公开了一种噻唑基新烟碱化合物及其制备方法和应用。所述的噻唑基新烟碱类化合物的结构式如式IR1为氢、甲基或乙基，R2为氢、甲基、2‑氯‑5‑噻唑甲基或6‑氯‑3‑吡啶甲基，先通过2‑氯‑5‑氯甲基噻唑与乙胺反应生成2‑氯‑5‑乙胺基甲基噻唑，再由1,1‑二氯硝基乙烯或者1,1,1，‑三氯硝基乙烷与2‑氯‑5‑乙胺基甲基噻唑和化合物R1NH2R2在碱的存在下反应制得。本发明的噻唑基新烟碱类化合物可单独制备杀虫剂，也可与其他农药混合制备杀虫剂。本发明的噻唑基新烟碱类化合物具有杀虫活性高、低毒、杀虫谱广等优点，对于飞虱、蚜虫等均有明显杀虫效果。

  公开号：

  CN107474022B

文献信息

• Alpha-unsaturated amines, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0302389A2

  公开（公告）日：1989-02-08

  α-Unsaturated amines of the formula: wherein X¹ and X² are such that one is an electron-­attracting group with the other being a hydrogen atom or an electron-attracting group; R¹ is a group attached through a nitrogen atom; R² is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  式中α-不饱和胺： 式中：X¹和X²一个是引电子基团，另一个是氢原子或引电子基团；R¹是通过氮原子连接的基团；R²是氢原子或通过碳原子、氮原子或氧原子连接的基团；n是等于0、1或2的整数；A是杂环基团或环烃基团；描述了其盐类及其作为杀虫剂和/或杀螨剂的农用化学品用途。
• Stable agrochemical compositions
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0496106A1

  公开（公告）日：1992-07-29

  Stable agrochemical compositions are provided by incorporating at least one of the α -unsaturated amine derivatives having the following formula: wherein one of X¹ and X² is an electron attracting group and the other is hydrogen or an electron attracting group; R¹ is a group attached through a nitrogen atom; R² is hydrogen or a group attached through a carbon, nitrogen, or oxygen atom; n is an integer of 0, 1, or 2; and A is a substituted or unsubstituted heterocyclic group or a substituted or unsubstituted cyclic hydrocarbon group; and salts thereof, into an agrochemically acceptable solid carrier (clay minerals capable of adsorption (including fuller's earth, terra alba, bentonite, and activated fuller's earth), zeolite, activated charcoal, and β -cyclodextrin, etc.) under a pH 5.5 or less condition. The agrochemical (pesticidal) compositions exert potent shelf life and light-resistance.

  通过掺入至少一种具有下式的α-不饱和胺衍生物，可提供稳定的农用化学品组合物： 其中 X¹ 和 X² 中的一个是引电子基团，另一个是氢或引电子基团；R¹ 是通过氮原子连接的基团；R² 是氢或通过碳原子、氮原子或氧原子连接的基团；n 是 0、1 或 2 的整数；和 A 是取代或未取代的杂环基团或取代或未取代的环烃基团；以及它们的盐，在 pH 值为 5.5 或更高的条件下，加入到农业化学上可接受的固体载体（可吸附的粘土矿物（包括富勒土、白土、膨润土和活性富勒土）、沸石、活性炭和 β - 环糊精等）中。在 pH 值为 5.5 或更低的条件下使用。农用化学品（杀虫剂）组合物具有很强的保质期和耐光性。
• Intermediates, their production and their use for preparing alpha-unsaturated amines
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0529680A2

  公开（公告）日：1993-03-03

  α-unsaturated amines of the formula: wherein X¹ and X² are such that one is an electron-attracting group with the other being a hydrogen atom or an electron-attracting group; R¹ is a group attached through a nitrogen atom; R² is a hydrogen atom or a group attached through a carbon, nitrogen or oxygen atom; n is an integer equal to 0, 1 or 2; A is a heterocyclic group or a cyclic hydrocarbon group, and salts thereof and their agrochemical use as insecticidal and/or miticidal agents are described.

  式中α-不饱和胺： 其中，X¹和X²一个是引电子基团，另一个是氢原子或引电子基团；R¹是通过氮原子连接的基团；R²是氢原子或通过碳原子、氮原子或氧原子连接的基团；n是等于0、1或2的整数；A是杂环基团或环烃基团。
• Synergistic insecticidal compositions
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0617890A1

  公开（公告）日：1994-10-05

  Novel insecticidal compositions of the compounds of the formula. wherein R represents hydrogen atom, acyl, alkyl or an optionally substitutable heteroarylalkyl, A represents hydrogen atom, alkyl, or a divalent group connected to B, B represents alkyl, -S-R, or a divalent group or atom connected to A, wherein R has the same meaning as mentioned above, Y represents = N- or wherein T1 represents hydrogen atom or an optionally substitutable alkyl, and X represents an electron attractive group, and methylenedioxybenzene derivatives.

  式化合物的新型杀虫组合物，其中R代表氢原子、酰基、烷基或可任选取代的杂芳基烷基，A代表氢原子、烷基或与B相连的二价基团，B代表烷基、-S-R或与A相连的二价基团或原子，其中R的含义与上述相同，Y代表＝N-或其中T1代表氢原子或可任选取代的烷基，X代表引电子基团，以及亚甲二氧基苯衍生物。
• A method of killing noxious insects
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0632957A1

  公开（公告）日：1995-01-11

  A method of killing noxious insects with the use of either a shaped article having a projecting part and previously coated with a particular active compound or a shaped article having a projecting portion and provided with a spout for discharging said active compound is applied pressure from outside onto and around the stalks and/or stems of fruit vegetables, flowers and ornamental plants, thereby making the surfaces of said stalks and/or stems forcibly absorb the active compound.

  一种杀灭有害昆虫的方法，使用一个具有突出部分并事先涂有特定活性化合物的异形物品，或一个具有突出部分并配有用于排出所述活性化合物的喷嘴的异形物品，从外部向果蔬、花卉和观赏植物的茎秆和/或周围施加压力，从而使所述茎秆和/或表面强制吸收活性化合物。