2-cyclohexyl-2-hexanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-cyclohexyl-2-hexanol
• 英文别名: 2-Cyclohexyl-hexan-2-ol；2-cyclohexylhexan-2-ol
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: ADXCWONRKVEJLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  溴丁基-镁 、 乙酰基环己烷 以 乙醚 为溶剂， 反应 1.0h， 生成 2-cyclohexyl-2-hexanol
  参考文献：
  名称：

  在TADDOLate镁的制备和机理方面，对碳环和杂环芳基酮高度对映选择性地添加伯烷基格氏试剂

  摘要：

  在等摩尔量的α，α，α'，α'-四苯基-2,2-二甲基-1,3-二氧戊环-4,5-二甲醇（TADDOL）伯碱试剂（Et， Pr，Bu，Oct，3-丁烯基）在-100°C下加到THF中的碳和杂芳族甲基酮中，得到对映体过量的叔醇，其值超过98％。研究了该方法的范围和局限性。在剧烈搅拌的非均质混合物中发生的反应在没有反应中心的空间位阻的情况下提供了最佳结果。由烷基溴制得的格氏试剂优于由氯化物制得的试剂。TADDOL的ee与2-苯基-2-癸醇的产品的ee之间存在完美的线性关系；那些大专绝对构型已知的醇是由酮羰基的Re面通过亲核攻击形成的。讨论了反应的立体化学过程的三种暂定机理模型。

  DOI：

  10.1016/s0040-4020(01)90463-6

文献信息

• trans-1-Sulfonylamino-2-isoborneolsulfonylaminocyclohexane Derivatives: Excellent Chiral Ligands for the Catalytic Enantioselective Addition of Organozinc Reagents to Ketones
  作者：Vicente J. Forrat、Oscar Prieto、Diego J. Ramón、Miguel Yus

  DOI：10.1002/chem.200501397

  日期：2006.5.24

  The catalytic enantioselective addition of different organozinc reagents (such as alkyl and aryl derivatives or in situ generated aryl, allyl alkenyl, and alkynyl derivatives obtained through different transmetallation processes) to simple ketones has been accomplished by using titanium tetraisopropoxide and chiral ligands derived from substituted trans-1-sulfonylamino-2-isoborneolsulfonylaminocyclohexane

  通过使用四异丙氧基钛和衍生自取代的反式-1-磺酰基氨基-2-异冰片醇磺酰基氨基环己烷，生成相应的叔醇，对映体过量（ee）最高> 99％。描述了一种简单有效的合成这些反应中使用的手性配体的方法。
• Composition for reducing malodors and method for using the same
  申请人：——

  公开号：US20030199402A1

  公开（公告）日：2003-10-23

  A composition for reducing malodors in the air and on inanimate surfaces comprises a combination of at least one malodor neutralizing agent, at least one malodor binding agent, at least one malodor masking agent, and at least one performance agent. In accordance with one embodiment of the invention, the composition includes a surfactant component, a water dispersible polymer component, a metallic salt, a fragrance component, and a liquid carrier.

  一种用于减少空气中和无生命表面恶臭的组合物由至少一种恶臭中和剂、至少一种恶臭结合剂、至少一种恶臭掩盖剂和至少一种性能剂组合而成。根据本发明的一个实施方案，组合物包括表面活性剂成分、水分散聚合物成分、金属盐、香料成分和液体载体。
• First enantioselective addition of diethylzinc and dimethylzinc to prostereogenic ketones catalysed by camphorsulfonamide-titanium alkoxide derivatives
  作者：Diego J Ramón、Miguel Yus

  DOI：10.1016/s0040-4020(98)00236-1

  日期：1998.5

  The reaction of diethylzinc or dimethylzinc with prostereogenic ketones, in the presence of a stoichiometric amount of titanium tetraisopropoxide and a catalytic amount (20%) of camphorsulfonamide derivatives as chiral ligands leads to the formation of the corresponding enantioenriched tert-alcohols with enantiomeric ratios up to 94.5 : 5.5. The best results were obtained when phenones are used as substrates independently of the dialkylzinc reagent. The enantioselectivity shows a linear relationship with the enantiomeric excess of the ligand and seems to be independent of the reaction yield. A tentative catalytic cycle and mechanistic model are proposed for this new reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.
• Composition for reducing fabric wrinkles and method for using the same
  申请人：——

  公开号：US20040092423A1

  公开（公告）日：2004-05-13

  A composition for reducing fabric wrinkles is provided that generally comprises a silicone compound, a wetting agent, a drying agent, a liquid carrier, and a fragrance. The composition is preferably water clear, provides wrinkle reduction in a variety of fabrics, and is rapidly evaporated from the fabric. In accordance with one aspect of an exemplary embodiment of the invention, the wrinkle reducing composition does not employ a fragrance solubilizing agent.
• US4719105A
  申请人：——

  公开号：US4719105A

  公开（公告）日：1988-01-12