4-Acetyl-3-chloro-6-phenylpyridazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Acetyl-3-chloro-6-phenylpyridazine
• 英文别名: 1-(3-Chloro-6-phenylpyridazin-4-yl)ethanone；1-(3-chloro-6-phenylpyridazin-4-yl)ethanone
• 化学式: C₁₂H₉ClN₂O
• 分子量: 232.669
• InChiKey: ADZZJXRUOGRQHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Acetyl-3-chloro-6-phenylpyridazine 在 溶剂黄146 作用下， 以92%的产率得到4-acetyl-6-phenylpyridazin-3(2H)-one
  参考文献：
  名称：

  A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-chloropyridazines.

  摘要：

  The homolytic substitution of protonated 3-chloro-6-methylpyridazine 1a, followed by hydrolysis with AcOH affords 4- or 4,5-functionalized pyridazinones 3a-c. Less reactivity is found for 3-chloro-6-phenylpyridazine 1b. Hypotheses about these different behaviour patterns are proposed and discussed.

  DOI：

  10.1016/s0040-4039(00)79259-8
• 作为产物：
  描述：

  叔丁基过氧化氢 、 3-氯-6-苯基哒嗪 、 乙醛 在 硫酸 、 双氧水 、 iron(II) sulfate 作用下， 以 丙酮 为溶剂， 反应 0.08h， 以24%的产率得到4-Acetyl-3-chloro-6-phenylpyridazine
  参考文献：
  名称：

  A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-chloropyridazines.

  摘要：

  The homolytic substitution of protonated 3-chloro-6-methylpyridazine 1a, followed by hydrolysis with AcOH affords 4- or 4,5-functionalized pyridazinones 3a-c. Less reactivity is found for 3-chloro-6-phenylpyridazine 1b. Hypotheses about these different behaviour patterns are proposed and discussed.

  DOI：

  10.1016/s0040-4039(00)79259-8

文献信息

• [EN] PYRAZOLOPYRIDAZINE DERIVATIVES, PROCESS FOR PREPARATION AND USE FOR THE INHIBITION OF GSK-3<br/>[FR] DERIVES DE PYRAZOLOPYRIDAZINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION POUR L'INHIBITION DE GSK-3
  申请人：GLAXO GROUP LTD

  公开号：WO2003080616A1

  公开（公告）日：2003-10-02

  Certain compounds of formula (I) or a salt thereof and/or a solvate thereof, wherein, R1, R2 and R3 are as defined in the specification, processes for the preparation of such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.
• A new two-step procedure for functionalized-3(2H)-pyridazinones through homolytic substitution of 3-chloropyridazines.
  作者：Vittorio Dal Piaz、Maria Paola Giovannoni、Giovanna Ciciani

  DOI：10.1016/s0040-4039(00)79259-8

  日期：1993.6

  The homolytic substitution of protonated 3-chloro-6-methylpyridazine 1a, followed by hydrolysis with AcOH affords 4- or 4,5-functionalized pyridazinones 3a-c. Less reactivity is found for 3-chloro-6-phenylpyridazine 1b. Hypotheses about these different behaviour patterns are proposed and discussed.