cis-ethyl 4-(m-nitrophenyl)-1-phenylsulfonylazetidine-2-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-ethyl 4-(m-nitrophenyl)-1-phenylsulfonylazetidine-2-carboxylate
• 英文别名: ethyl (2S,4R)-1-(benzenesulfonyl)-4-(3-nitrophenyl)azetidine-2-carboxylate
• 化学式: C₁₈H₁₈N₂O₆S
• 分子量: 390.417
• InChiKey: AEDCUZSWZADUBC-SJORKVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  ethyl (dimethylsulfuranylidene)acetate 、 吖丙啶,2-(3-硝基苯基)-1-(苯磺酰)- 以 N,N-二甲基甲酰胺 为溶剂， 以24%的产率得到cis-ethyl 4-(m-nitrophenyl)-1-phenylsulfonylazetidine-2-carboxylate
  参考文献：
  名称：

  Reaction of N-arylsulfonylaziridines with dimethylsulfoniumethoxycarbonyl methylide: regio- and stereo-selective synthesis of 1-arylsulfonyl-2-ethoxycarbonyl azetidines

  摘要：

  Synthesis and characterization of 4-aryl-, 3,4-diaryl- and 3-alkyl-4-aryl-N-arylsulfonylazetidines, bearing a 2-ethoxycarbonyl group are described. The methodology used involves transfer of an ethoxycarbonyl substituted methylene group from dimethylsulfoniumethoxycarbonyl methylide to N-arylsulfonylaziridines. The synthesis is both regio- and stereo-selective.

  DOI：

  10.1039/p19950002605

文献信息

• Reaction of N-arylsulfonylaziridines with dimethylsulfoniumethoxycarbonyl methylide: regio- and stereo-selective synthesis of 1-arylsulfonyl-2-ethoxycarbonyl azetidines
  作者：Upender K. Nadir、Anjali Arora

  DOI：10.1039/p19950002605

  日期：——

  Synthesis and characterization of 4-aryl-, 3,4-diaryl- and 3-alkyl-4-aryl-N-arylsulfonylazetidines, bearing a 2-ethoxycarbonyl group are described. The methodology used involves transfer of an ethoxycarbonyl substituted methylene group from dimethylsulfoniumethoxycarbonyl methylide to N-arylsulfonylaziridines. The synthesis is both regio- and stereo-selective.