1,3-dimethyl-5,8-dihydro-5-(4-methoxyphenyl)pyrimido[4,5-d]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,3-dimethyl-5,8-dihydro-5-(4-methoxyphenyl)pyrimido[4,5-d]pyrimidine-2,4-dione
• 英文别名: 5-(4-Methoxyphenyl)-1,3-dimethyl-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4-dione；5-(4-methoxyphenyl)-1,3-dimethyl-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4-dione
• 化学式: C₁₅H₁₆N₄O₃
• 分子量: 300.317
• InChiKey: AEXFQOAVJQGVBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-二甲基-6-氨基脲嘧啶 在 乙酸铵 、 2,4-滴二甲胺盐 、 溶剂黄146 作用下， 反应 2.05h， 生成 1,3-dimethyl-5,8-dihydro-5-(4-methoxyphenyl)pyrimido[4,5-d]pyrimidine-2,4-dione
  参考文献：
  名称：

  在无溶剂条件下通过三组分一锅缩合高效区域特异性合成高度官能化的新型二氢嘧啶并[4,5-d]嘧啶衍生物

  摘要：

  6-[(二甲氨基)亚甲基]氨基尿嘧啶、醛和乙酸铵在乙酸存在下的环保三组分缩合提供了具有生物学意义的新型二氢嘧啶[4,5-d]的一锅法合成在无溶剂条件下以高产率获得嘧啶衍生物。

  DOI：

  10.1055/s-2007-970739

文献信息

• Microwave-Promoted Catalyst- and Solvent-Free Aza-Diels–Alder Reaction of Aldimines with 6-[2-(Dimethylamino)vinyl]-1,3-dimethyluracil
  作者：Rupam Sarma、Manas M. Sarmah、Dipak Prajapati

  DOI：10.1021/jo202346w

  日期：2012.2.17

  A microwave-promoted aza-Diels Alder reaction between 6[2-(dimethylamino)vinyl]-1,3-dimethyluracil and aldimines has been developed for the construction of dihydropyrido[4,3-d]pyrimidines. Urea is effectively employed as an environmentally benign source of ammonia in the absence of any catalyst or solvent. The key step in the reaction is in situ generation and trapping of the reactive aldimine formed from urea and aldehyde by the diene system of the uracil. The reaction is clean, and excellent yields are obtained in a matter of a few minutes.
• An Efficient Regiospecific Synthesis of Highly Functionalized Novel Dihydropyrimido[4,5-<i>d</i>]pyrimidine Derivatives by a Three-Component One-Pot ­Condensation under Solvent-Free Conditions
  作者：Dipak Prajapati、Kalyan Borah、Mukut Gohain

  DOI：10.1055/s-2007-970739

  日期：——

  condensation of 6-[(dimethylamino)methylene]amino uracil, an aldehyde, and ammonium acetate in the presence of acetic acid afforded a one-pot synthesis of biologically significant novel dihydropyrimido[4,5-d]pyrimidine derivatives in high yields under solvent-free conditions.

  6-[(二甲氨基)亚甲基]氨基尿嘧啶、醛和乙酸铵在乙酸存在下的环保三组分缩合提供了具有生物学意义的新型二氢嘧啶[4,5-d]的一锅法合成在无溶剂条件下以高产率获得嘧啶衍生物。