6-trimethylsilanylmethyl cyclohex-1-enecarboxylic acid ethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-trimethylsilanylmethyl cyclohex-1-enecarboxylic acid ethyl ester
• 英文别名: Ethyl 6-(trimethylsilylmethyl)cyclohexene-1-carboxylate
• 化学式: C₁₃H₂₄O₂Si
• 分子量: 240.418
• InChiKey: AKFCZYXSNHESES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (三甲基硅基)甲基氯化镁 、 6-乙酰氧基环己烯-1-羧酸乙酯 在 Br₂Cu^(1-)*Li⁽¹⁺⁾ 作用下， 以 四氢呋喃 为溶剂， 以78%的产率得到6-trimethylsilanylmethyl cyclohex-1-enecarboxylic acid ethyl ester
  参考文献：
  名称：

  Short Synthesis of Functionalized Cyclic Homoallylsilanes

  摘要：

  The synthesis of functionalized cyclic homoallylsilanes 5 and 6 was described starting from functional cycloalkenols 1 and 2, in which the addition of silylcuprate to the functional acetates 3 and 4 were used as the key reaction step.

  DOI：

  10.1080/00397910500297370

文献信息

• Short Synthesis of Functionalized Cyclic Homoallylsilanes
  作者：Rim Ouled Saad、Taoufik Turki、Hassen Amri

  DOI：10.1080/00397910500297370

  日期：2005.11

  The synthesis of functionalized cyclic homoallylsilanes 5 and 6 was described starting from functional cycloalkenols 1 and 2, in which the addition of silylcuprate to the functional acetates 3 and 4 were used as the key reaction step.