sodium 2,3-dihydro-1H-inden-2-yl[(2-oxopyrrolidin-1-yl)methyl]phosphinate

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: sodium 2,3-dihydro-1H-inden-2-yl[(2-oxopyrrolidin-1-yl)methyl]phosphinate
• 英文别名: sodium;2,3-dihydro-1H-inden-2-yl-[(2-oxopyrrolidin-1-yl)methyl]phosphinate
• 化学式: C₁₄H₁₇NO₃P*Na
• 分子量: 301.257
• InChiKey: AKMBFMSDUVFZAY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.62
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  bis(trimethylsilyl) (indan-2-yl)phosphonite 在 sodium methylate 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 生成 sodium 2,3-dihydro-1H-inden-2-yl[(2-oxopyrrolidin-1-yl)methyl]phosphinate
  参考文献：
  名称：

  具有茚满部分的新型官能化羟基和氨基甲基次膦酸盐的合成

  摘要：

  AbstractThe convenient synthesis of new functionalized organophosphorus acids and their derivatives containing indan moieties was developed. The regioselective radical addition of bis(trimethylsiloxy)phosphine to indene proceeds to give rise to 2‐indanylphosphonite as key compound for preparation of above acids with bicyclic substituents. Azobis(isobutyronitrile) (AIBN) in the conditions of its thermolysis was used as effective initiator of the addition reaction. The further treatment of organophosphorus acids trimethylsilyl esters with the methanolic sodium methoxide solution resulted in the water‐soluble sodium salts of the corresponding acids.

  DOI：

  10.1002/hc.21419

文献信息

• Synthesis of new functionalized hydroxy- and aminomethylphosphinates with indan moieties
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1002/hc.21419

  日期：2018.3

  AbstractThe convenient synthesis of new functionalized organophosphorus acids and their derivatives containing indan moieties was developed. The regioselective radical addition of bis(trimethylsiloxy)phosphine to indene proceeds to give rise to 2‐indanylphosphonite as key compound for preparation of above acids with bicyclic substituents. Azobis(isobutyronitrile) (AIBN) in the conditions of its thermolysis was used as effective initiator of the addition reaction. The further treatment of organophosphorus acids trimethylsilyl esters with the methanolic sodium methoxide solution resulted in the water‐soluble sodium salts of the corresponding acids.