N-(2-(ethylamino)ethyl)pentacosa-10,12-diynamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-(ethylamino)ethyl)pentacosa-10,12-diynamide
• 英文别名: N-(10,12-pentacosadiynoyl)-N'-ethylethylenediamine；N-[2-(ethylamino)ethyl]pentacosa-10,12-diynamide
• 化学式: C₂₉H₅₂N₂O
• 分子量: 444.745
• InChiKey: AKVJOSPMCXZIBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  32
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-(ethylamino)ethyl)pentacosa-10,12-diynamide 在 氢溴酸 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以65%的产率得到N'-ethyl-2-pentacosa-10,12-diynamidoethanaminium bromide
  参考文献：
  名称：

  Polydiacetylene paper-based colorimetric sensor array for vapor phase detection and identification of volatile organic compounds

  摘要：

  检测和识别气相中的挥发性有机化合物对于安全和质量评估至关重要。本研究利用八种双乙炔单体制备了一种新型纸基聚二乙炔（PDA）比色传感器阵列平台，其中六种为双亲性单体，另外两种为双亲性单体。为了制造传感器，使用滴铸技术将单体涂覆在滤纸表面，然后通过紫外线照射将其转化为 PDA。PDA 传感器在暴露于挥发性有机化合物蒸汽时会出现溶剂诱导的不可逆颜色转换。当组合成传感阵列时，通过 RGB 值测量和主成分分析 (PCA) 统计分析的颜色变化模式能够区分气相中 18 种不同的挥发性有机化合物。PCA 分数和载荷图还允许将阵列中的传感元件从八个减少到三个 PDA，从而能够对 18 种挥发性有机化合物进行分类。利用仅包含两个 PDA 的阵列，成功地对汽油、汽油醇和柴油等各种汽车燃料进行了分类。

  DOI：

  10.1039/c2jm16273c
• 作为产物：
  描述：

  10,12-二十五碳二炔酸 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 N-(2-(ethylamino)ethyl)pentacosa-10,12-diynamide
  参考文献：
  名称：

  Self-Assembly of Biocidal Nanotubes from a Single-Chain Diacetylene Amine Salt

  摘要：

  We describe the facile two-step synthesis of nanotubes that form pure, well-defined, nanostructured materials. We have synthesized a secondary amine HBr salt as the headgroup of a single-chain diacetylenic lipid. This molecule can form a number of different self-assembled nanostructures in aqueous or organic solvents. In water, this lipid forms a monodisperse preparation of nanotubes at high yields. Partially dissolving a preparation of nanotubes dried from aqueous solution results in a remarkably organized structure that resembles a nanocarpet. Details of the nanotube structure were investigated by scanning electron microscopy, transmission electron microscopy, and small-angle X-ray spectroscopy. The aqueous nanotubes have a cross-sectional diameter of 89 nm. The walls of the tubes are an exquisitely uniform 27 nm thick and are shown to consist of five lipid bilayers with a repeat spacing of 57.8 Angstrom. The chemical structure of the material shows no chiral centers, but suspensions of the nanotubes in an aqueous medium show an unexpected circular dichroism signal. The versatility of this new material as a platform for nanostructure design and synthesis is enhanced by its biocidal activity. This antimicrobial activity along with the regularity the nanostructures will enhance the development of a range of applications from biosensors to artificial retinas.

  DOI：

  10.1021/ja048463i

文献信息

• Polydiacetylenes carrying amino groups for colorimetric detection and identification of anionic surfactants
  作者：Wanwisa Thongmalai、Thichamporn Eaidkong、Sasikarn Ampornpun、Radeemada Mungkarndee、Gamolwan Tumcharern、Mongkol Sukwattanasinitt、Sumrit Wacharasindhu

  DOI：10.1039/c1jm12795k

  日期：——

  A series of diacetylene lipids carrying primary amine, secondary amine or ammonium head groups are prepared and converted to blue polydiacetylene (PDA) sols by UV irradiation. The blue to pink colorimetric transition of polymerized diacetylenes in the presence of anionic surfactants such as sodium dodecanoate (SDC), sodium docecyl sulphate (SDS), and sodium dodecyl benzene sulphate (SDBS) are observed by the naked eye at the micromolar concentration level while there is no change with cationic surfactants and little response with nonionic surfactants. An identification of common anionic surfactants can be accomplished based on a combination of the colorimetric pattern of structurally diverse PDAs using the principal component analysis technique. Moreover, PDA was successfully fabricated on filter paper and the colorimetric response of PDA embedded on the paper was investigated which allowed the direct colorimetric detection of anionic surfactants.

  制备了一系列带有伯胺、仲胺或铵头基团的二乙炔脂质，并通过紫外线照射将其转化为蓝色聚二乙炔（PDA）溶胶。在十二酸钠（SDC）、十二烷基硫酸钠（SDS）和十二烷基苯硫酸钠（SDBS）等阴离子表面活性剂存在的情况下，肉眼可观察到聚合后的二乙炔在微摩尔浓度水平上由蓝色转变为粉红色，而阳离子表面活性剂则没有变化，非离子表面活性剂也几乎没有反应。利用主成分分析技术，结合不同结构的 PDA 的比色模式，可以识别常见的阴离子表面活性剂。此外，还成功地在滤纸上制作了 PDA，并研究了嵌入滤纸上的 PDA 的比色反应，从而可以直接比色检测阴离子表面活性剂。
• End-to-end joining of nanotubes
  申请人：Russell Alan J.

  公开号：US20100137541A1

  公开（公告）日：2010-06-03

  A method for joining nanotubes end-to-end, includes contacting the nanotubes with a joining fluid. The joining fluid has at least one property that is different from at least one property associated with ends of the nanotubes. In one embodiment, the method further includes contacting the nanotubes with a first, treating fluid and removing the bulk first fluid before the nanotubes are contacted with the joining fluid. The joining fluid is immiscible in the treating fluid to effect end-to-end joining of the nanotubes.

  一种将纳米管端对端连接的方法，包括将纳米管与连接液接触。连接液具有至少一种与纳米管端相关的属性不同。在一种实施例中，该方法还包括将纳米管与第一处理液接触，并在纳米管与连接液接触之前去除大部分第一液体。连接液与处理液不相溶，以实现纳米管的端对端连接。
• WO2006/85896
  申请人：——

  公开号：——

  公开（公告）日：——
• Self assembled nanostructures and mehods for preparing the same
  申请人：Russell J. Alan

  公开号：US20070232699A1

  公开（公告）日：2007-10-04

  The present invention provides amphiphilic diacetylene compounds, and compositions and self-assembled nanotubes containing the same. Also provided are methods of producing the compounds, compositions, and nanotubes of the invention, and methods of destroying or inhibiting the growth or proliferation of microorganisms using the nanotubes of the present invention.
• US7666911B2
  申请人：——

  公开号：US7666911B2

  公开（公告）日：2010-02-23