10-undecenoic acid 4-chlorobutyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-undecenoic acid 4-chlorobutyl ester
• 英文别名: 4-Chlorobutyl undec-10-enoate
• 化学式: C₁₅H₂₇ClO₂
• 分子量: 274.831
• InChiKey: AMCILSOJOSOALJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 10-十一碳烯基氯酸 在 三氯化硼 作用下， 反应 3.0h， 以82%的产率得到10-undecenoic acid 4-chlorobutyl ester
  参考文献：
  名称：

  ONE-POT SYNTHESIS OF ω-CHLOROESTERS VIA THE REACTION OF ACID CHLORIDES WITH TETRAHYDROFURAN IN THE PRESENCE OF TRICHLOROBORANE

  摘要：

  The reaction of acid chlorides with tetrahydrofuran in the presence of trichloroborane produces omega-chloroesters in excellent yields.

  DOI：

  10.1081/scc-120004849

文献信息

• Direct ni mediated synthesis of ketones from acyl bromides and grignard reagents
  作者：Corrado Malanga、Laura A. Aronica、Luciano Lardicci

  DOI：10.1016/0040-4039(95)01936-c

  日期：1995.12

  a catalytic amount of NidppeCl(2) converts an acyl bromide directly into ketones at 0 degrees C in THF in the presence of a Grignard reagent. The described procedure represents a useful way to afford dialkyl, diaryl or alkyl aryl ketones as well as 1,2-diketones. In the adopted reaction conditions double bonds, esters and ketones are unaffected.
• ONE-POT SYNTHESIS OF ω-CHLOROESTERS VIA THE REACTION OF ACID CHLORIDES WITH TETRAHYDROFURAN IN THE PRESENCE OF TRICHLOROBORANE
  作者：Rama R. Malladi、George W. Kabalka

  DOI：10.1081/scc-120004849

  日期：2002.1

  The reaction of acid chlorides with tetrahydrofuran in the presence of trichloroborane produces omega-chloroesters in excellent yields.