2-(2-Chloro-phenyl)-8-iodo-6-methyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(2-Chloro-phenyl)-8-iodo-6-methyl-chromen-4-one
• 英文别名: 2-(2-Chlorophenyl)-8-iodo-6-methylchromen-4-one
• 化学式: C₁₆H₁₀ClIO₂
• 分子量: 396.612
• InChiKey: AMNZUBSPHPMXCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[(2-氯苯基)-哌啶-1-基甲基]哌啶 、 2-Bromo-1-(2-hydroxy-3-iodo-5-methylphenyl)ethanone 以 甲醇 为溶剂， 反应 0.17h， 以64%的产率得到2-(2-Chloro-phenyl)-8-iodo-6-methyl-chromen-4-one
  参考文献：
  名称：

  New flavones by a novel synthetic route

  摘要：

  Twelve new flavones ((3) under bar) were prepared by the reaction of 2-hydroxy-alpha-bromoacetophenones ((1) under bar) with piperidine or morpholine animals of benzaldeydes ((2) under bar) in refluxing methanol. The products ((3) under bar) were fully characterised by H-1 NMR and IR spectroscopy and MS spectrometry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00628-5

文献信息

• New flavones by a novel synthetic route
  作者：Angela Sandulache、Alexandru Cascaval、Nicoletta Toniutti、Angelo G. Giumanini

  DOI：10.1016/s0040-4020(97)00628-5

  日期：1997.7

  Twelve new flavones ((3) under bar) were prepared by the reaction of 2-hydroxy-alpha-bromoacetophenones ((1) under bar) with piperidine or morpholine animals of benzaldeydes ((2) under bar) in refluxing methanol. The products ((3) under bar) were fully characterised by H-1 NMR and IR spectroscopy and MS spectrometry. (C) 1997 Elsevier Science Ltd.