1-[(2-氯苯基)-哌啶-1-基甲基]哌啶 | 34595-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-[(2-氯苯基)-哌啶-1-基甲基]哌啶
• 英文名称: 1,1'-(2-chloro-phenylmethanediyl)-bis-piperidine
• 英文别名: Piperidine, 1,1'-(o-chlorobenzylidene)di-；1-[(2-chlorophenyl)-piperidin-1-ylmethyl]piperidine
• CAS: 34595-24-9
• 化学式: C₁₇H₂₅ClN₂
• 分子量: 292.852
• InChiKey: JHVCQIAKEPKKMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  1-[(2-氯苯基)-哌啶-1-基甲基]哌啶 在 甲酸 作用下， 以 various solvent(s) 为溶剂， 生成 哌啶 、 1-[(2-氯苯基)甲基]哌啶
  参考文献：
  名称：

  Fukawa, Hidemichi; Suzuki, Kunio; Sekiya, Minoru, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 10, p. 2868 - 2873

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 2-氯苯甲醛 以 水 为溶剂， 反应 3.0h， 以99%的产率得到1-[(2-氯苯基)-哌啶-1-基甲基]哌啶
  参考文献：
  名称：

  Preparation of aminals in water

  摘要：

  Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal. Here we report for the first time that aminals can be prepared and isolated in pure water without a catalyst in high yield and purity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.02.021

文献信息

• Nucleophilic difluoromethylation of N,N-acetals with TMSCF2SO2Ph reagent promoted by trifluoroacetic acid: A facile access to α-difluoromethylated tertiary amines
  作者：Weizhou Huang、Chuanfa Ni、Yanchuan Zhao、Bing Gao、Jinbo Hu

  DOI：10.1016/j.jfluchem.2012.05.018

  日期：2012.11

  A protocol for the synthesis of difluoromethylated tertiary amines by nucleophilic difluoromethylation of N,N-acetals using TMSCF2SO2Ph reagent is developed. The reaction proceeds smoothly in 1,4-dioxane using K2CO3 as the initiator. A key feature of the reaction is that the in situ generated iminiums (from N,N-acetals and CF3COOH) could be fluoroalkylated in an efficient way. (C) 2012 Elsevier B.V. All rights reserved.
• New flavones by a novel synthetic route
  作者：Angela Sandulache、Alexandru Cascaval、Nicoletta Toniutti、Angelo G. Giumanini

  DOI：10.1016/s0040-4020(97)00628-5

  日期：1997.7

  Twelve new flavones ((3) under bar) were prepared by the reaction of 2-hydroxy-alpha-bromoacetophenones ((1) under bar) with piperidine or morpholine animals of benzaldeydes ((2) under bar) in refluxing methanol. The products ((3) under bar) were fully characterised by H-1 NMR and IR spectroscopy and MS spectrometry. (C) 1997 Elsevier Science Ltd.
• Preparation of aminals in water
  作者：Václav Jurčı́k、René Wilhelm

  DOI：10.1016/j.tet.2004.02.021

  日期：2004.3

  Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal. Here we report for the first time that aminals can be prepared and isolated in pure water without a catalyst in high yield and purity. (C) 2004 Elsevier Ltd. All rights reserved.
• Fukawa, Hidemichi; Suzuki, Kunio; Sekiya, Minoru, Chemical and pharmaceutical bulletin, 1980, vol. 28, # 10, p. 2868 - 2873
  作者：Fukawa, Hidemichi、Suzuki, Kunio、Sekiya, Minoru

  DOI：——

  日期：——