syn-1-phenyl-2,2-difluoro-3-hydroxy-3-(4-chlorophenyl)propyl diethyl phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: syn-1-phenyl-2,2-difluoro-3-hydroxy-3-(4-chlorophenyl)propyl diethyl phosphate
• 英文别名: [(1R,3R)-3-(4-chlorophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropyl] diethyl phosphate
• 化学式: C₁₉H₂₂ClF₂O₅P
• 分子量: 434.804
• InChiKey: ANDDRDPQXHROTE-QZTJIDSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 、 、 syn-1-phenyl-2,2-difluoro-3-hydroxy-3-(4-chlorophenyl)propyl diethyl phosphate 、 anti-1-phenyl-2,2-difluoro-3-hydroxy-3-(4-chlorophenyl)propyl diethyl phosphate
  参考文献：
  名称：

  Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate

  摘要：

  A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2009.02.015

文献信息

• Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate
  作者：Anastasia V. Alexandrova、Petr Beier

  DOI：10.1016/j.jfluchem.2009.02.015

  日期：2009.5

  A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols. (C) 2009 Elsevier B.V. All rights reserved.