(2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)propane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)propane-1,2-diamine
• 化学式: C₉H₁₉N₄PolS₂
• 分子量: 268.4
• InChiKey: ANFTUSVMWWOELJ-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  3-氯-2-丁酮 、 (2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)propane-1,2-diamine 以 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-3-benzyl-1-methyl-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one
  参考文献：
  名称：

  Synthesis of Chiral Polyaminothiazoles

  摘要：

  An efficient approach toward the parallel solid-phase synthesis of highly diversified chiral polyaminothiazoles employing Hantzsc’s thiazole synthesis is presented. The treatment of resin-bound chiral polyamines with Fmoc-isothiocyanates generated polythioureas which were further reacted with a variety of α-halogenoketones to afford following cleavage from the solid support the desired chiral polyaminothiazoles in good yield and purity.

  DOI：

  10.1021/cc9001907
• 作为产物：
  描述：

  (S)-3-benzyl-1-methyl-5-phenyl-1H-benzo[e][1,4]-diazepin-2(3H)-one 在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2S)-1-N,2-N-bis(4-methyl-1,3-thiazol-2-yl)propane-1,2-diamine
  参考文献：
  名称：

  Synthesis of Chiral Polyaminothiazoles

  摘要：

  An efficient approach toward the parallel solid-phase synthesis of highly diversified chiral polyaminothiazoles employing Hantzsc’s thiazole synthesis is presented. The treatment of resin-bound chiral polyamines with Fmoc-isothiocyanates generated polythioureas which were further reacted with a variety of α-halogenoketones to afford following cleavage from the solid support the desired chiral polyaminothiazoles in good yield and purity.

  DOI：

  10.1021/cc9001907