(E)-1-(dimethylamino)-4,4,5,5,6,6,6-heptafluoro-1-hexen-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-1-(dimethylamino)-4,4,5,5,6,6,6-heptafluoro-1-hexen-3-one
• 英文别名: (E)-1-(dimethylamino)-4,4,5,5,6,6,6-heptafluorohex-1-en-3-one
• 化学式: C₈H₈F₇NO
• 分子量: 267.146
• InChiKey: APPQWLVKKHHFHE-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  己醛,3,3,4,4,5,5,6,6,6-九氟- 、 二甲胺 以 水 、 乙腈 为溶剂， 反应 2.0h， 以97%的产率得到(E)-1-(dimethylamino)-4,4,5,5,6,6,6-heptafluoro-1-hexen-3-one
  参考文献：
  名称：

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes with amines: a facile synthetic method for fluoroalkyl enaminoketones

  摘要：

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes (1) with amines (2) were studied. Both aliphatic amines and electron-deficient aromatic amines readily reacted with I in acetonitrile and water under reflux to give fluoroalkyl enaminoketones (3) in high yields, while no condensed products were obtained by reactions of 1 with electron-rich aromatic amines under similar conditions. In the presence of triethylamine, however, the reaction of 1 with electron-rich aromatic amines at room temperature gave 3 in low yields. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2003.11.005

文献信息

• Synthesis and Properties of β-Ethoxyvinyl Polyfluoroalkyl Ketones
  作者：Marine G. Gorbunova、Igor I. Gerus、Valery P. Kukhar

  DOI：10.1055/s-2000-6386

  日期：——

  A number of β-ethoxyvinyl polyfluoroalkyl ketones were synthesized by acylation of ethyl vinyl ether with acid chlorides containing polyfluoroalkyl groups of different composition and structure. Some typical nucleophilic reactions of the title compounds with amines were carried out. Two new fluoro-containing pyrimidinoles were synthesized by the reaction of β-ethoxyvinyl polyfluoroalkyl ketones with urea.

  通过含有不同组成和结构的聚氟烷基酸氯与乙烯基乙醚的酰基化反应，合成了一系列β-乙氧基乙烯基聚氟烷基酮。进行了这些标题化合物与胺类的一些典型亲核反应。通过β-乙氧基乙烯基聚氟烷基酮与脲的反应，合成了两种新的含氟嘧啶烷醇。
• Reactions of 2,2-dihydropolyfluoroalkylaldehydes with amines: a facile synthetic method for fluoroalkyl enaminoketones
  作者：Xian-Jin Yang、Jin-Tao Liu、Fu-Lu Zhao

  DOI：10.1016/j.jfluchem.2003.11.005

  日期：2004.3

  Reactions of 2,2-dihydropolyfluoroalkylaldehydes (1) with amines (2) were studied. Both aliphatic amines and electron-deficient aromatic amines readily reacted with I in acetonitrile and water under reflux to give fluoroalkyl enaminoketones (3) in high yields, while no condensed products were obtained by reactions of 1 with electron-rich aromatic amines under similar conditions. In the presence of triethylamine, however, the reaction of 1 with electron-rich aromatic amines at room temperature gave 3 in low yields. (C) 2003 Elsevier B.V. All rights reserved.