2-[1-(4-methylphenyl)-3-oxo-3-phenylpropyl]-1-cyclopentanone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-[1-(4-methylphenyl)-3-oxo-3-phenylpropyl]-1-cyclopentanone
• 英文别名: 2-[1-(4-Methylphenyl)-3-oxo-3-phenylpropyl]cyclopentan-1-one；2-[1-(4-methylphenyl)-3-oxo-3-phenylpropyl]cyclopentan-1-one
• 化学式: C₂₁H₂₂O₂
• 分子量: 306.404
• InChiKey: ASKKXXHSBMHFCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(1-环戊烯基)吗啉 、 (E)-3-(4-methylphenyl)-1-phenyl-2-propen-1-one 在 aluminum oxide 作用下， 反应 0.13h， 以86%的产率得到2-[1-(4-methylphenyl)-3-oxo-3-phenylpropyl]-1-cyclopentanone
  参考文献：
  名称：

  Alumina-promoted fast solid-phase Michael addition of enamines with conjugated enones under microwave irradiation

  摘要：

  A fast alumina-promoted solid-phase Michael addition of enamines to conjugated enones is described under microwave irradiation in high yields. The 1,5-diketo Michael adducts have been converted into a novel class of 1',2'-diazepino(17,16-d') steroids. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02049-4

文献信息

• Alumina-promoted fast solid-phase Michael addition of enamines with conjugated enones under microwave irradiation
  作者：Utpal Sharma、Utpal Bora、Romesh C Boruah、Jagir S Sandhu

  DOI：10.1016/s0040-4039(01)02049-4

  日期：2002.1

  A fast alumina-promoted solid-phase Michael addition of enamines to conjugated enones is described under microwave irradiation in high yields. The 1,5-diketo Michael adducts have been converted into a novel class of 1',2'-diazepino(17,16-d') steroids. (C) 2001 Elsevier Science Ltd. All rights reserved.