bis(5-((1E,7E)-nona-1,7-dien-3,5-diyn-1-yl)furan-2-yl)isopropane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bis(5-((1E,7E)-nona-1,7-dien-3,5-diyn-1-yl)furan-2-yl)isopropane
• 英文别名: 2-[1-methyl-1-[5-[(1E,7E)-nona-1,7-dien-3,5-diynyl]-2-furyl]ethyl]-5-[(1E,7E)-nona-1,7-dien-3,5-diynyl]furan；2-[(1E,7E)-nona-1,7-dien-3,5-diynyl]-5-[2-[5-[(1E,7E)-nona-1,7-dien-3,5-diynyl]furan-2-yl]propan-2-yl]furan
• 化学式: C₂₉H₂₄O₂
• 分子量: 404.508
• InChiKey: AVKKXFNTADZWHW-AKZXQIKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苍术素 、 丙酮 在 盐酸 、 溶剂黄146 作用下， 反应 9.0h， 以38%的产率得到bis(5-((1E,7E)-nona-1,7-dien-3,5-diyn-1-yl)furan-2-yl)isopropane
  参考文献：
  名称：

  A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives

  摘要：

  A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the alpha, beta-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2011.10.015

文献信息

• A new 9-nor-atractylodin from Atractylodes lancea and the antibacterial activity of the atractylodin derivatives
  作者：Yanjun Chen、Yuxue Wu、Hexiang Wang、Kun Gao

  DOI：10.1016/j.fitote.2011.10.015

  日期：2012.1

  A new compound, namely, 9-nor-atractylodin (1) and one known atractylodin (2) were isolated from the rhizomes of Atractylodes lancea. The structural modifications of atractylodin were carried out and a series of atractylodin derivatives (3-10) were obtained. The antibacterial activities of 1-10 were examined against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Compounds 4 and 8, which contained the alpha, beta-unsaturated carbonyl fragment, were found to be active against E. coli and S. aureus. (C) 2011 Elsevier B.V. All rights reserved.