10-[2-(9-carboxynonanoyloxy)propoxy]-10-oxodecanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 10-[2-(9-carboxynonanoyloxy)propoxy]-10-oxodecanoic acid
• 化学式: C₂₃H₄₀O₈
• 分子量: 444.566
• InChiKey: AWWLBDKDUMNCIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  癸二酸 、 1,2-丙二醇 在 对甲苯磺酸 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 6.0h， 以79%的产率得到10-[2-(9-carboxynonanoyloxy)propoxy]-10-oxodecanoic acid
  参考文献：
  名称：

  A novel ^99m Tc-diester complex as tumor targeting agent: Synthesis, radiolabeling, and biological distribution study

  摘要：

  本研究的目标是合成一种新的二酯衍生物，并用一种最有效的诊断放射性同位素进行放射性标记，研究其作为一种新型靶向放射性示踪剂用于肿瘤成像。10-[2-(9-Carboxynanoyloxy)propoxy]-10-oxodecanoic acid 的合成收率极高，并通过傅立叶变换红外光谱、质量、1H-NMR 和 13C-NMR 光谱对其进行了表征。以二亚硫酸钠为还原剂，通过直接技术对二酯类进行了锝-99m（99mTc）放射性标记。二酯用量、还原剂用量、介质 pH 值和反应时间等标记参数均已优化。合成的二酯与 Tc-99m 复合物的放射化学收率高达 95.10 ± 0.41%，在血清中的体外稳定性可达 12 小时。二酯对乳腺癌细胞株（MCF-7）的抗癌活性评估显示，在 100 μg/ml 的浓度下，二酯的抑制率高达 61.5%。由于锝和铼的化学性质非常相似，因此合成了二酯的铼复合物，并通过液相色谱-质谱法（ESI）和元素分析对其进行了表征。99mTc 二酯复合物的生物分布研究表明，注射后 30 分钟，肿瘤小鼠的靶向与非靶向比（T/NT）为 6.24 ± 0.09，表明该复合物有望用作实体瘤成像剂。

  DOI：

  10.1002/jlcr.3841

文献信息

• Antifouling coating
  申请人：Nippon Paint Co., Ltd.

  公开号：EP1138725B1

  公开（公告）日：2007-09-12
• INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS
  申请人：Yissum Research Development Company of The Hebrew University of Jerusalem

  公开号：EP2453940A2

  公开（公告）日：2012-05-23
• RENEWABLY DERIVED THERMOPLASTIC POLYESTER-BASED URETHANES AND METHODS OF MAKING AND USING THE SAME
  申请人：Trent University

  公开号：US20170145145A1

  公开（公告）日：2017-05-25

  The disclosure generally provides high-molecular-weight thermoplastic polyester-based urethanes (TPEUs). In some embodiments, the component monomers of the TPEUs are entirely derived from renewable sources. The disclosure also provides methods of making high-molecular-weight TPEUs, and, in particular, methods for achieving such high molecular weights. The disclosure also provides certain uses of such TPEUs. Entirely lipid-derived segmented thermoplastic TPEU elastomers with rubber-like properties such as low modulus and high elongation were produced by incorporating 1,9-nonanediol (ND) as chain extender with oleic acid derived polyester diols (PEDs) and 1,7-heptamethylene diisocyanate (HPMDI). Enhanced elastomeric properties were achieved by optimizing hydrogen bond density and phase separation of the TPEU via customized polymerization protocols. The novel TPEUs showed extensive degradation under hydrothermal ageing in water at 80° C. and achieved a tensile half-life in one day of immersion. For the first time, entirely lipid-derived TPEU elastomers with thermal and mechanical properties comparable to commercially available petroleum-based analogues and a controlled life-cycle were achieved, demonstrating the viability of potential alternatives to petroleum-derived elastomers and credible potential in biomedical applications especially as bio-resorbable implants or tissue scaffolds.
• READY-MADE BIOMEDICAL DEVICES FOR IN VIVO WELDING
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

  公开号：US20170333604A1

  公开（公告）日：2017-11-23

  Disclosed herein is a unique family of medical implants which are engineered outside of a subject's body into a form which may be manipulated in vivo. The implants comprise a region of at least one weldable material which allows welding of the implant to a polymeric material introduced into the body prior to, together with or after the implant has been positioned.
• US3945955A
  申请人：——

  公开号：US3945955A

  公开（公告）日：1976-03-23