2-fluoro-1-(3-(trifluoromethyl)phenyl)ethan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoro-1-(3-(trifluoromethyl)phenyl)ethan-1-one
• 英文别名: 2-Fluoro-1-(3-(trifluoromethyl)phenyl)ethanone；2-fluoro-1-[3-(trifluoromethyl)phenyl]ethanone
• 化学式: C₉H₆F₄O
• 分子量: 206.14
• InChiKey: BCZZAISAAQRMLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  间三氟甲基苯乙酮 在 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2,2,2]octane-1,4-bis(tetrafluoroborate) 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以10%的产率得到2-fluoro-1-(3-(trifluoromethyl)phenyl)ethan-1-one
  参考文献：
  名称：

  使用Accufluor TM -NFTh氟化试剂可高产率地对酮进行直接氟官能化

  摘要：

  使用1-氟-4-羟基-1,4-二氮杂双环[2,2,2]辛烷双（四氟硼酸酯）[Accufluor TM -NFTh]在乙腈溶液中。

  DOI：

  10.1016/0040-4039(96)00630-2

文献信息

• METHOD FOR PROMOTING PLANT GROWTH
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150282482A1

  公开（公告）日：2015-10-08

  The present invention provides a method for promoting plant growth, which comprises treating a plant with a compound represented by the following Formula (1): provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (8) is excluded: (1) Methyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (2) Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (3) Methyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (4) Methyl 7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (5) Ethyl 4-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (6) Ethyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, (7) Ethyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, and (8) Ethyl 7-(trifluoromethyl)benzo[b]thiophene-2-carboxylate.

  本发明提供了一种促进植物生长的方法，包括用下式表示的化合物处理植物： 只要排除用与以下任一化合物相对应的化合物处理植物的促进植物生长方法：(1) 甲基4-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(2) 甲基5-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(3) 甲基6-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(4) 甲基7-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(5) 乙基4-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(6) 乙基5-(三氟甲基)苯并[b]噻吩-2-羧酸酯，(7) 乙基6-(三氟甲基)苯并[b]噻吩-2-羧酸酯，以及(8) 乙基7-(三氟甲基)苯并[b]噻吩-2-羧酸酯。
• [EN] 4-(PHENYLMETHYL AND SUBSTITUTED PHENYLMETHYL)-IMIDAZOLE-2-THIONES ACTING AS SPECIFIC ALPHA2 ADRENERGIC AGONISTS<br/>[FR] 4-(PHENYLMETHYL ET SUBSTITUES DE PHENYLMETHYLS)-IMIDAZOLE-2-THIONES AGISSANT COMME AGONISTES ADRENERGIQUES ALPHA2 SPECIFIQUES
  申请人：ALLERGAN INC

  公开号：WO2006036480A1

  公开（公告）日：2006-04-06

  Compounds of Formula (1), where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of Formula (1) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of Formula (1) which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.

  公式（1）的化合物，其中变量的含义如规范中定义的，是α2肾上腺素受体的激动剂。本公开的几种化合物对α2B和/或α2C肾上腺素受体具有特异性或选择性，而不是对α2A肾上腺素受体。此外，一些所述的化合物没有或只有极小的心血管和/或镇静活性。公式（1）的化合物在哺乳动物中，包括人类，作为治疗对α2肾上腺素受体激动剂响应的疾病和/或缓解条件的药物是有用的。具有无明显心血管和/或镇静活性的公式（1）的化合物可用于治疗疼痛和其他症状，副作用极小。
• Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional <i>N</i> , <i>N</i> ‐Dimethylamides and Tetramethylurea in Toluene
  作者：Dimitrije Djukanovic、Benjamin Heinz、Francesca Mandrelli、Serena Mostarda、Paolo Filipponi、Benjamin Martin、Paul Knochel

  DOI：10.1002/chem.202102805

  日期：2021.10.7

  The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-dimethylamides including easily enolizable amides at −20 °C within 27 sec, producing highly functionalized ketones in 48–90 % yield (36 examples)

  各种芳基或杂芳基溴化物在 THF（1.0 当量）与sec- BuLi（1.1 当量）存在下在甲苯中的连续流动反应，在 25°C 下在 40 秒内提供相应的芳基锂，该芳基锂被各种官能化的N、N -酰化二甲基酰胺，包括易于烯醇化的酰胺，可在 -20 °C 下在 27 秒内以 48-90% 的产率生成高度官能化的酮（36 个实例）。该方法非常适用于制备 α-手性酮，例如萘普生和布洛芬衍生的酮，其ee为 99% 。两种不同的锂有机金属化合物与 1,1,3,3-四甲脲 (TMU) 的一锅逐步双加成以 69-79% 的产率提供不对称酮（9 个例子）。
• [EN] PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS<br/>[FR] MODULATEURS DES RECEPTEURS ACTIVES PAR LES PROLIFERATEURS DE PEROXYSOMES
  申请人：LILLY CO ELI

  公开号：WO2005054176A1

  公开（公告）日：2005-06-16

  The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

  本发明涉及一种式（I）的化合物，或其药学上可接受的盐、溶剂合物、水合物或立体异构体，可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的疾病，如X综合征、2型糖尿病、高血糖、高脂血症、肥胖、凝血障碍、高血压、动脉粥样硬化以及其他与X综合征和心血管疾病相关的疾病。
• Peroxisome proliferator activated receptor modulators
  申请人：Canada Jane Emily

  公开号：US20070082907A1

  公开（公告）日：2007-04-12

  The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

  本发明涉及一种式（I）的化合物，或其药学上可接受的盐、溶剂水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖激活受体（PPAR）介导的疾病，例如X综合征、2型糖尿病、高血糖、高脂血症、肥胖症、凝血障碍、高血压、动脉硬化和其他与X综合征和心血管疾病相关的疾病。