6-p-chlorophenyl-3-p-fluorophenyl-7H-s-triazolo[3,4-b][1,3,4]thiadiazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-p-chlorophenyl-3-p-fluorophenyl-7H-s-triazolo[3,4-b][1,3,4]thiadiazine
• 英文别名: 6-(4-chlorophenyl)-3-(4-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
• 化学式: C₁₆H₁₀ClFN₄S
• mdl: MFCD04028398
• 分子量: 344.8
• InChiKey: BDJDZKXZVWSDON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氟苯甲酰肼 在 一水合肼 、 potassium hydroxide 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 生成 6-p-chlorophenyl-3-p-fluorophenyl-7H-s-triazolo[3,4-b][1,3,4]thiadiazine
  参考文献：
  名称：

  Synthesis and Evaluation of Antiphlogistic Activity of Some New 4-Fluorophenyltriazolothiadiazines

  摘要：

  The reaction between 4-fluorobenzoic acid hydrazide (1) and carbon disulfide in the existence of alcoholic potassium hydroxide yielded N?-(4-fluoro-benzoyl)-hydrazinecarbodithioic acid (2). Subsequently, product 2 on reaction with an aqueous solution of hydrazine hydrate led to the formation of compound 3. The condensation of compound 3 with various substituted ?-bromoacetophenones in ethanol furnished the targeted triazolothiadiazines, bearing a 4-fluorophenyl moiety (4a-l). Subsequently, a comprehensive evaluation of the antiphlogistic potential of the synthesized molecules 4a-l was conducted. This assessment was completed using albino Wistar rats that had their paws swollen with carrageenan. Compounds 4l and 4b demonstrated significant (P < 0.01) antiphlogistic activity. Furthermore, compounds 4d, 4f, and 4k exhibited noteworthy antiphlogistic effects (P < 0.05), comparable to the standard drug indomethacin. This study sheds light on the antiphlogistic properties of these compounds and holds promise for further research in this area. . KEYWORDS :Antiphlogistic, Anti-inflammatory, 4-Fluorophenyl, Triazole, Thiadiazine.

  DOI：

  10.59467/ijhc.2024.34.1

文献信息

• Mohan, Jag, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 2, p. 403 - 406
  作者：Mohan, Jag

  DOI：——

  日期：——