Fv80

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Fv80
• 英文别名: 4-(6,6,9,9-Tetramethyl-4-oxo-7,8-dihydrobenzo[g]chromen-2-yl)benzoic acid
• 化学式: C₂₄H₂₄O₄
• 分子量: 376.452
• InChiKey: BECZKSGJBYIETC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯甲酰基苯甲酸甲酯 在 吡啶 、 氢氧化钾 、 硫酸 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 0.5h， 生成 Fv80
  参考文献：
  名称：

  Retinobenzoic acids. 2. Structure-activity relationships of chalcone-4-carboxylic acids and flavone-4'-carboxylic acids

  摘要：

  The structure-activity relationships of (E)-chalcone-4-carboxylic acids, which are retinoidal benzoic acids represented by R-Ph-X-Ph-COOH (4, X = -COCH = CH-), are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60. The activity was increased by the substitution of a bulky alkyl group(s) (R), and among such compounds, (E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid (Ch55) and (E)-4-[3-oxo-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1 -propenyl]benzoic acid (Ch80) are several times more active than retinoic acid. Though the stable conformer of chalcone derivatives is linear (s-cis form), the conformationally restricted analogue 4-(6,7,8,9-tetrahydro-6,6,9,9-tetramethyl-4H-4-oxonaphtho[2,3-b]py ran-2-yl)benzoic acid (Fv80) is more active than Ch80. While the effect of introduction of an oxygen atom varied, 4-[1-hydroxy-3-oxo-3-(5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2 - naphthalenyl)-1-propenyl]benzoic acid (Re80), regarded as a derivative of Ch80 with two additional hydroxyl groups, has very strong activity.

  DOI：

  10.1021/jm00124a016

文献信息

• Use of synthetic retinoids for osteopathy
  申请人：HOECHST JAPAN LIMITED

  公开号：EP0619116A2

  公开（公告）日：1994-10-12

  An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.

  一种抗骨病组合物，其活性成分包括下式（I）、（II）或（III）所代表的化合物： 可用于治疗和预防骨质疏松症，如骨质疏松症和骨折。
• Flavone carboxylic acid derivatives
  申请人：Shudo, Koichi, Prof. Dr.

  公开号：EP0237986B1

  公开（公告）日：1991-10-02
• KAGECHIKA, HIROYUKI;KAWACHI, EMIKO;HASHIMOTO, YUICHI;SHUDO, KOICHI, J. MED. CHEM., 32,(1989) N, C. 834-840
  作者：KAGECHIKA, HIROYUKI、KAWACHI, EMIKO、HASHIMOTO, YUICHI、SHUDO, KOICHI

  DOI：——

  日期：——
• US4831052A
  申请人：——

  公开号：US4831052A

  公开（公告）日：1989-05-16
• US4925979A
  申请人：——

  公开号：US4925979A

  公开（公告）日：1990-05-15