2-(4-(trifluoromethyl)phenyl)imidazo[2,1-a]isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-(trifluoromethyl)phenyl)imidazo[2,1-a]isoquinoline
• 英文别名: 2-(4-trifluoromethylphenyl)imidazo[2,1-a]isoquinoline；2-[4-(Trifluoromethyl)phenyl]imidazo[2,1-a]isoquinoline
• 化学式: C₁₈H₁₁F₃N₂
• 分子量: 312.294
• InChiKey: BEJYIZCNYXUDGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异喹啉 、 (Z)-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride 、 2-溴苯乙酮 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以93%的产率得到2-(4-(trifluoromethyl)phenyl)imidazo[2,1-a]isoquinoline
  参考文献：
  名称：

  Facile three-component domino reactions for the synthesis of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines

  摘要：

  The three-component domino reactions of pyridine/isoquinoline, phenacyl bromide, and substituted (E)-N-hydroxyarylimidoyl chloride in the presence of triethylamine afforded a series of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines. This one pot three-component transformation presumably proceeds via ylide generation/annulation/fragmentation/clehydration domino sequence of reactions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.126

文献信息

• Facile three-component domino reactions for the synthesis of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines
  作者：Pitchaimani Prasanna、Sundaravel Vivek Kumar、Pethaiah Gunasekaran、Subbu Perumal

  DOI：10.1016/j.tetlet.2013.04.126

  日期：2013.7

  The three-component domino reactions of pyridine/isoquinoline, phenacyl bromide, and substituted (E)-N-hydroxyarylimidoyl chloride in the presence of triethylamine afforded a series of 2-arylimidazo[1,2-a]pyridines and 2-arylimidazo[2,1-a]isoquinolines. This one pot three-component transformation presumably proceeds via ylide generation/annulation/fragmentation/clehydration domino sequence of reactions. (C) 2013 Elsevier Ltd. All rights reserved.