N-(3,4,5-trimethylthiazol-2(3H)-ylidene)propan-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(3,4,5-trimethylthiazol-2(3H)-ylidene)propan-2-amine
• 化学式: C₉H₁₆N₂S
• 分子量: 184.305
• InChiKey: BFBWRUHVHKBBJK-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.29
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  、 异硫氰酸异丙酯 以 甲苯 为溶剂， 反应 16.0h， 以51%的产率得到N-(3,4,5-trimethylthiazol-2(3H)-ylidene)propan-2-amine
  参考文献：
  名称：

  Novel isothiocyanate transposition in 2-alkyliminothiazoles: a simple solution for regiochemical problem

  摘要：

  Novel alkyl/aryl transposition in the reaction of 2-iminothiazoles with alkyl/aryl isothiocyanates was found out, and the reaction was very easy to handle and gave good to excellent chemical yields. Moreover, transposition reaction provided a simple but excellent solution for regiochemical problems in 2-iminothiazole synthesis. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.02.084

文献信息

• Novel isothiocyanate transposition in 2-alkyliminothiazoles: a simple solution for regiochemical problem
  作者：Dongyun Shin、Jihoon Lee、Kee Dal Nam、Hoh-Gyu Hahn

  DOI：10.1016/j.tetlet.2007.02.084

  日期：2007.4

  Novel alkyl/aryl transposition in the reaction of 2-iminothiazoles with alkyl/aryl isothiocyanates was found out, and the reaction was very easy to handle and gave good to excellent chemical yields. Moreover, transposition reaction provided a simple but excellent solution for regiochemical problems in 2-iminothiazole synthesis. (c) 2007 Elsevier Ltd. All rights reserved.