丙烷-1,1,2-三羧酸 | 61713-72-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙烷-1,1,2-三羧酸
• 英文名称: Propantricarbonsaeure
• 英文别名: propane-1,1,2-tricarboxylic acid；Propan-1,1,2-tricarbonsaeure
• CAS: 61713-72-2
• 化学式: C₆H₈O₆
• 分子量: 176.126
• InChiKey: PCOWRECNVZIBKD-UHFFFAOYSA-N

物化性质

• 沸点：
  146-147 °C(Press: 10 Torr)
• 密度：
  1.0683 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  丙烷-1,1,2-三羧酸 在 氯 、 硝基苯 作用下， 生成 (+/-)-erythro-2-chloro-3-methyl-succinic acid
  参考文献：
  名称：

  Hesse; Breig, Justus Liebigs Annalen der Chemie, 1955, vol. 592, p. 120

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 丙烷-1,1,2-三羧酸
  参考文献：
  名称：

  Bone; Quarendon, Proceedings of the Royal Society of London, Series A: Mathematical, Physical and Engineering Sciences, 1926, vol. 110, p. 541

  摘要：

  DOI：

文献信息

• [EN] 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS<br/>[FR] DÉRIVÉS DE 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE COMME INHIBITEURS DE FAK/PYK2
  申请人：CENTAURUS BIOPHARMA CO LTD

  公开号：WO2012092880A1

  公开（公告）日：2012-07-12

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

  这项发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物，以及利用这些化合物抑制FAK和/或Pyk2并治疗由FAK和/或Pyk2介导的疾病或疾病的方法。
• Synthese d'une pyridazine d'interet therapeutique, marquee au carbone 14: Dichlorhydrate de morpholinoethylamino-3 methyl-4 phenyl-6 pyridazine 14C-6 (30,038 CB)
  作者：L. Pichat、J. P. Beaucourt、F. Krausz、C. Moulineau

  DOI：10.1002/jlcr.2580120303

  日期：1976.7

  Benzoyl chloride-714C is condensed with tris(trimethylsilyl) 1-lithio-1,1,2 propane tricarboxylate, which after hydrolysis gives rise to a 66% yield of 2-methyl-3-(benzoyl-7-14C) propionic acid. After cyclisation with hydrazine, followed by treatment with bromine in acetic acid, 3-hydroxy-4-methyl-6-phenyl pyndazine 6-14C is secured in a 77% yield. This hydroxypyridazine treated with POCl3 gave a 90% yield of 90 % pure 4-methyl-6-phenyl-3-chloropyndazine 6-14C; The latter treated with 2-morpholino-1-aminoethane in presence of sodium iodide has given 3-morpholinoethylamino 4-methyl 6-phenylpyndazine 6-14C. The overall yield based on barium carbonate 14C is 16.7 % (specific activity 18.5 mCi/mMole).

  苯甲酰氯-714C 与 1-二硫代-1,1,2-丙烷三羧酸三（三甲基硅基）酯缩合，水解后生成 2-甲基-3-（苯甲酰基-7-14C）丙酸，产率为 66%。用肼环化后，再用溴在乙酸中处理，可得到 3-羟基-4-甲基-6-苯基哒嗪 6-14C，收率为 77%。用 POCl3 处理这种羟基哒嗪，可以得到 90% 纯度的 4-甲基-6-苯基-3-氯哒嗪 6-14C；后者在碘化钠存在下用 2-吗啉基-1-氨基乙烷处理，可以得到 3-吗啉基乙基氨基 4-甲基 6-苯基哒嗪 6-14C。碳酸钡 14C 的总收率为 16.7%（比活度为 18.5 mCi/mMole）。
• CHITOSAN/ACIDIC BIOPOLYMER HYBRID FIBER AND CULTURE BASE FOR ANIMAL CELLS
  申请人：Chemical Biology Institute

  公开号：EP1533366A1

  公开（公告）日：2005-05-25

  It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10 % of FBS (fetal bovine serum)at room temperature for 2 weeks.

  其目的是提供一种适合培养软骨细胞和成纤维细胞等动物细胞的三维支架。这些三维支架由壳聚糖/酸性生物聚合物混合纤维组成，纤维内部由壳聚糖或其盐类组成，纤维表面涂有壳聚糖与可生物降解的酸性生物聚合物的复合物，纤维在室温下放置2周后仍能保持其形状。
• Chitosan/acidic biopolymer hybrid fiber and culture base for animal cells
  申请人：Majima Tokifumi

  公开号：US20060134158A1

  公开（公告）日：2006-06-22

  It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10% of FBS (fetal bovine serum) at room temperature for 2 weeks.

  其目的是提供一种适合培养软骨细胞和成纤维细胞等动物细胞的三维支架。这些三维支架由壳聚糖/酸性生物聚合物混合纤维组成，纤维内部由壳聚糖或其盐类组成，纤维表面涂有壳聚糖与可生物降解的酸性生物聚合物的复合物，纤维在室温下放置2周后仍能保持其形状。
• Backer; Buining, Recueil des Travaux Chimiques des Pays-Bas, 1928, vol. 47, p. 1007
  作者：Backer、Buining

  DOI：——

  日期：——