2-cyclohexyl-2-methoxyethanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-cyclohexyl-2-methoxyethanal
• 英文别名: 2-Cyclohexyl-2-methoxyacetaldehyde；2-cyclohexyl-2-methoxyacetaldehyde
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: BJDZWBQRBDMRCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  对甲砜基甲苯 、 2-cyclohexyl-2-methoxyethanal 在 四甲基乙二胺 、 氯磷酸二乙酯 、 lithium diisopropyl amide 作用下， 生成 、
  参考文献：
  名称：

  (Alkoxyallyl)sulfones as enal and enone β-anion equivalents. Synthesis of mono-, di- and trisubtituted furans

  摘要：

  Treatment of variously-substituted (alkoxyallyl)sulfones 1, 7-9 with strong base followed by aldehydes gives alcohol adducts 5. These may be converted into a wide range of substituted furans 6 by exposure to acid, or to silica gel in dichloromethane containing sulfuric acid in some cases. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4020(96)00932-5

文献信息

• Diastereoselective Synthesis of α-Oxyaminesvia Gold-, Silver- and Copper-Catalyzed, Three-Component Couplings of α-Oxyaldehydes, Alkynes, and Amines in Water
  作者：Baosheng Huang、Xiaoquan Yao、Chao-Jun Li

  DOI：10.1002/adsc.200606118

  日期：2006.8

  The three-component couplings of α-oxyaldehydes, alkynes, and amines in water were investigated by using gold, silver and copper catalysts. Gold(I) was found to be the most effective catalyst in this reaction to afford propargylamines in good yields and moderate diastereoselectivities. On the other hand, silver catalysts show the best catalytic activities on non-coordinating α-alkyl-substituted aldehydes

  通过使用金，银和铜催化剂研究了水中的α-氧化醛，炔烃和胺的三组分偶联。发现金（I）是该反应中以高收率和中等非对映选择性提供炔丙基胺的最有效催化剂。另一方面，银催化剂对非配位的α-烷基取代的醛显示出最佳的催化活性。
• (Alkoxyallyl)sulfones as enal and enone β-anion equivalents. Synthesis of mono-, di- and trisubtituted furans
  作者：Donald Craig、Christopher J. Etheridge

  DOI：10.1016/s0040-4020(96)00932-5

  日期：1996.11

  Treatment of variously-substituted (alkoxyallyl)sulfones 1, 7-9 with strong base followed by aldehydes gives alcohol adducts 5. These may be converted into a wide range of substituted furans 6 by exposure to acid, or to silica gel in dichloromethane containing sulfuric acid in some cases. Copyright (C) 1996 Elsevier Science Ltd