3-(3-nitrophenyl)-2-phenyl-1H-indole | 1446648-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(3-nitrophenyl)-2-phenyl-1H-indole
• CAS: 1446648-34-5
• 化学式: C₂₀H₁₄N₂O₂
• 分子量: 314.343
• InChiKey: BJJWHCXFSMZFGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.41
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.93
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-苯基吲哚 在 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 barium(II) hydroxide 作用下， 以 乙二醇二甲醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 3-(3-nitrophenyl)-2-phenyl-1H-indole
  参考文献：
  名称：

  Allosteric modulators of CB1 cannabinoid receptors

  摘要：

  本发明涉及新颖的杂环衍生物，它们是大麻素受体1（CB1）的别构调节剂，可用于治疗或预防与内大麻素功能障碍和涉及大麻素受体CB1亚型的神经和精神障碍相关的疾病；涉及它们的制备方法；包括它们的药物组合物；以及使用它们的方法。

  公开号：

  US09556118B2

文献信息

• [EN] ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS<br/>[FR] MODULATEURS ALLOSTÉRIQUES DE RÉCEPTEURS DE CANNABINOÏDES CB1
  申请人：UNIV NORTHEASTERN

  公开号：WO2013103967A1

  公开（公告）日：2013-07-11

  The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

  本发明涉及新的杂环衍生物，它们是大麻素受体1（CB1）的别构调节剂，可用于治疗或预防与内源性大麻素功能障碍有关的神经和精神障碍以及涉及大麻素受体CB1亚型的疾病；涉及它们的制备方法；涉及包含它们的制药组合物；以及使用它们的方法。
• ALLOSTERIC MODULATORS OF CB1 CANNABINOID RECEPTORS
  申请人：Northeastern University

  公开号：US20150005346A1

  公开（公告）日：2015-01-01

  The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

  本发明涉及新型杂环衍生物，它们是大麻素受体1（CB1）的别构调节剂，并且适用于治疗或预防与内源性大麻素功能障碍和涉及CB1亚型的大麻素受体相关的神经和精神障碍以及疾病；涉及它们的制备方法；涉及包含它们的制药组合物；以及使用它们的方法。
• Allosteric Modulators of CB1 Cannabinoid Receptors
  申请人：Northeastern University

  公开号：US20170197918A1

  公开（公告）日：2017-07-13

  The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
• US9556118B2
  申请人：——

  公开号：US9556118B2

  公开（公告）日：2017-01-31
• Allosteric modulators of CB1 cannabinoid receptors
  申请人：Northeastern University

  公开号：US09556118B2

  公开（公告）日：2017-01-31

  The present invention relates to novel heterocyclic derivatives which are allosteric modulators of cannabinoid receptor 1 (CB1) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with endocannabinoid dysfunction and diseases in which the CB1 subtype of cannabinoid receptor is involved; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

  本发明涉及新颖的杂环衍生物，它们是大麻素受体1（CB1）的别构调节剂，可用于治疗或预防与内大麻素功能障碍和涉及大麻素受体CB1亚型的神经和精神障碍相关的疾病；涉及它们的制备方法；包括它们的药物组合物；以及使用它们的方法。