2-carboxybenzaldehyde thiosemicarbazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-carboxybenzaldehyde thiosemicarbazone
• 英文别名: 2-[(carbamothioylhydrazinylidene)methyl]benzoic acid
• 化学式: C₉H₉N₃O₂S
• 分子量: 223.255
• InChiKey: BJLGMFGFJVYGIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氨基硫脲 、 邻羧基苯甲醛 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.67h， 以65%的产率得到2-carboxybenzaldehyde thiosemicarbazone
  参考文献：
  名称：

  Synthesis, spectroscopic, anticancer and antibacterial studies of Ni(II) and Cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone

  摘要：

  Ni(II) and Cu(II) complexes of 2-carboxybenzaldehyde thiosemicarbazone (L) were synthesized and investigated by their spectral and analytical data. These newly synthesized complexes have a composition of M(L)X(H2O)(2) (where M = Ni(II), Cu(II) and X = Cl-, NO-, (CHCOO-)-C-3) and (L) is the tridentate Schiff base ligand. The ligand and its complexes have been characterized on the basis of analytical, molar conductivity, magnetic susceptibility measurements, FT-IR, ESR, H-1 NMR and electronic spectral analysis. All the compounds were non-electrolytic in nature. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) and a tetragonal geometry for Cu(II) complexes. The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby-Bauer single disk susceptibility test. (C) 2014 Published by Elsevier B.V.

  DOI：

  10.1016/j.saa.2014.02.141

文献信息

• Synthesis, spectroscopic, anticancer and antibacterial studies of Ni(II) and Cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone
  作者：Sulekh Chandra、Vandana

  DOI：10.1016/j.saa.2014.02.141

  日期：2014.8

  Ni(II) and Cu(II) complexes of 2-carboxybenzaldehyde thiosemicarbazone (L) were synthesized and investigated by their spectral and analytical data. These newly synthesized complexes have a composition of M(L)X(H2O)(2) (where M = Ni(II), Cu(II) and X = Cl-, NO-, (CHCOO-)-C-3) and (L) is the tridentate Schiff base ligand. The ligand and its complexes have been characterized on the basis of analytical, molar conductivity, magnetic susceptibility measurements, FT-IR, ESR, H-1 NMR and electronic spectral analysis. All the compounds were non-electrolytic in nature. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) and a tetragonal geometry for Cu(II) complexes. The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby-Bauer single disk susceptibility test. (C) 2014 Published by Elsevier B.V.