4-hydroxypheny-O-b-D-glucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hydroxypheny-O-b-D-glucopyranoside
• 英文别名: (2S,3R,4R,5S,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
• 化学式: C₁₂H₁₆O₇
• 分子量: 272.255
• InChiKey: BJRNKVDFDLYUGJ-HHHUOAJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-hydroxypheny-O-b-D-glucopyranoside 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 对苯二酚
  参考文献：
  名称：

  New cytotoxic cycloartane triterpene from Cassia italica aerial parts

  摘要：

  Phytochemical study of the aerial parts of Cassia italica Mill. (family: Fabaceae) growing in Saudi Arabia afforded one new cycloartane triterpene, named (22E)-3-beta-hydroxycycloart-22-en-24-one (2), together with eight known compounds: beta-sitosterol (1), uvaol (3), daucosterol (4), methyl 3,4-dihydroxybenzoate (5), emodin (6), 4-hydroxypheny-O-beta-D-glucopyranoside (7), aloin (8) and rutin (9). The structure of the isolated compounds was determined by physical, chemical and spectral data (UV, IR, MS, 1D (H-1, C-13 and DEPT) and 2D (H-1 H-1 COSY, HSQC and HMBC) NMR), as well as by comparing with authentic samples. Compounds 3-5 and 7-9 were isolated for the first time from the plant. Compound 2 was evaluated for its cytotoxic activity against the L5178Y and PC12 cell lines. The total methanolic extract and compounds 5-9 exhibited free radical-scavenging activity using DPPH assay.

  DOI：

  10.1080/14786419.2014.902820

文献信息

• AGENT FOR EXTERNAL APPLICATION TO THE SKIN
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP1894558A1

  公开（公告）日：2008-03-05

  The present invention has an object to provide an agent for suppressing melanin production and/or inhibiting elastase activity containing a plant extract as an effective substance with high safety and acceptable levels of stability and odor or sediment formation and an agent for external application to the skin comprising the above agent which has excellent effects in skin-whitening and skin-beautifying. The object is attained by providing an agent for external application to the skin containing indigo-plant extract.

  本发明的目的是提供一种抑制黑色素生成和/或抑制弹性蛋白酶活性的制剂，该制剂含有一种植物提取物作为有效物质，安全性高，稳定性和气味或沉淀物的形成水平可接受，并提供一种由上述制剂组成的皮肤外用制剂，该制剂在皮肤美白和皮肤美容方面具有极佳的效果。通过提供一种含有靛蓝植物提取物的皮肤外用制剂，可以达到上述目的。
• TOPICAL DELIVERY SYSTEM FOR ACTIVE INGREDIENTS
  申请人：L'Oréal

  公开号：EP3393603A1

  公开（公告）日：2018-10-31
• TOPICAL DELIVERY SYSTEM FOR ACTIVE INREDIENTS
  申请人：L'OREAL

  公开号：US20180360705A1

  公开（公告）日：2018-12-20

  The present invention relates to a cosmetic composition, in particular a skin care cosmetic composition in the form of an oil-in-water (O/W) nano-emulsion having an oil phase dispersed in an aqueous phase as oil droplets with the size of less than 100 nm, for a keratin substance such as skin, said composition comprising (a) at least one oil; (b) at least one active ingredient; (c) water; and (d) at least one surfactant selected from nonionic surfactants and anionic surfactants; wherein the aqueous phase is substantially free from water soluble alcohol.
• [EN] TOPICAL DELIVERY SYSTEM FOR ACTIVE INGREDIENTS<br/>[FR] SYSTÈME D'ADMINISTRATION PAR VOIE TOPIQUE DE PRINCIPES ACTIFS
  申请人：OREAL

  公开号：WO2017110151A1

  公开（公告）日：2017-06-29

  The present invention relates to a cosmetic composition, in particular a skin care cosmetic composition in the form of an oil-in-water (O/W) nano-emulsion having an oil phase dispersed in an aqueous phase as oil droplets with the size of less than 100 nm, for a keratin substance such as skin, said composition comprising (a) at least one oil;(b) at least one active ingredient; (c) water; and (d) at least one surfactant selected from nonionic surfactants and anionic surfactants; wherein the aqueous phase is substantially free from water soluble alcohol.