2-butyl-4-chloro-5-(hydroxymetyl)-1-<<1-(2-carboxyfuran-3-yl)-4-phenyl>methyl>-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-butyl-4-chloro-5-(hydroxymetyl)-1-<<1-(2-carboxyfuran-3-yl)-4-phenyl>methyl>-1H-imidazole
• 英文别名: 3-[4-[[2-Butyl-4-chloro-5-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]furan-2-carboxylic acid
• 化学式: C₂₀H₂₁ClN₂O₄
• 分子量: 388.851
• InChiKey: BKPHYWLYBANUAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 5,5-dimethoxy-3-(4-methylphenyl)-2,3-epoxypentanoate 在 sodium hydroxide 、 N-溴代丁二酰亚胺(NBS) 、 4 A molecular sieve 、 水 、 sodium hydride 、 对甲苯磺酸 、 过氧化苯甲酰 作用下， 以 甲醇 、 四氯化碳 、 苯 为溶剂， 反应 26.0h， 生成 2-butyl-4-chloro-5-(hydroxymetyl)-1-<<1-(2-carboxyfuran-3-yl)-4-phenyl>methyl>-1H-imidazole
  参考文献：
  名称：

  Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

  摘要：

  With the aim of explaining the influence of the structural changes on the biphenylic moiety on the activity, a series of N-[(heterobiaryl)methyl]imidazoles (I), constructed on the model of DuPont compounds by replacing either the central or terminal phenyl ring with a heteroaromatic one, such as furan, thiophene, thiazole, and pyridine, was synthesized. Compared to the reference DuPont compound (EXP-7711), all the heterobiaryl derivatives showed a reduced potency both in receptor binding (rat adrenal capsular membranes) and in the functional assay (angiotensin II-induced contraction of rabbit aorta strips). The lower activity was justified by the extensive molecular modeling studies, which took into consideration the conformational and electrostatic features of several heterobiaryl derivatives. On the basis of the results obtained, it was hypothesized that the central aromatic ring of the biarylic portion works as a spacer, orienting in the right way the terminal phenyl ring, whose electronic distribution is, instead, crucial to its fitting well with a lipophilic pocket at the receptor site.

  DOI：

  10.1021/jm00049a012