2,2-difluoro-5-methyl-1-phenylhex-4-en-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-difluoro-5-methyl-1-phenylhex-4-en-1-one
• 化学式: C₁₃H₁₄F₂O
• 分子量: 224.25
• InChiKey: BNXCRXDVIYJBEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三甲基硅基苯甲酮 在 三氟甲磺酸三甲基硅酯 、 Gingras' reagent 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 2,2-difluoro-5-methyl-1-phenylhex-4-en-1-one
  参考文献：
  名称：

  Mixed organofluorine-organosilicon chemistry. 10. Allylation and benzylation of difluoroenoxysilanes. Application to the synthesis of gem -difluoroterpene analogues

  摘要：

  Acylsilane and trifluoromethyltrimethylsilane gave, under fluoride initiation, a difluoroenoxysilane which is used in situ in a Lewis add catalyzed coupling with a prenyl ester or a benzylic bromide. The advantage of this one-pot procedure was illustrated by its use in the synthesis of gcm-difluoro analogues of terpenes (dehydro-or-curcumene and or-turmerone). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00348-8

文献信息

• Mixed organofluorine-organosilicon chemistry. 10. Allylation and benzylation of difluoroenoxysilanes. Application to the synthesis of gem -difluoroterpene analogues
  作者：Olivier Lefebvre、Thierry Brigaud、Charles Portella

  DOI：10.1016/s0040-4020(99)00348-8

  日期：1999.6

  Acylsilane and trifluoromethyltrimethylsilane gave, under fluoride initiation, a difluoroenoxysilane which is used in situ in a Lewis add catalyzed coupling with a prenyl ester or a benzylic bromide. The advantage of this one-pot procedure was illustrated by its use in the synthesis of gcm-difluoro analogues of terpenes (dehydro-or-curcumene and or-turmerone). (C) 1999 Elsevier Science Ltd. All rights reserved.