1-(2-(3-(4-hydroxyphenyl)-2-(9-oxo-9,10-dihydroacridine-4carboxamido)propanamido)acetyl)pyrrolidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(2-(3-(4-hydroxyphenyl)-2-(9-oxo-9,10-dihydroacridine-4carboxamido)propanamido)acetyl)pyrrolidine-2-carboxylic acid
• 英文别名: (2S)-1-[2-[[(2S)-3-(4-hydroxyphenyl)-2-[(9-oxo-10H-acridine-4-carbonyl)amino]propanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid
• 化学式: C₃₀H₂₈N₄O₇
• 分子量: 556.575
• InChiKey: BOGSHHRJMGWIGB-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  41
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  165
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  二苯胺-2,2’二羧酸 在 硫酸 、 氯甲酸乙酯 、 三乙胺 、 lithium hydroxide 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.16h， 生成 1-(2-(3-(4-hydroxyphenyl)-2-(9-oxo-9,10-dihydroacridine-4carboxamido)propanamido)acetyl)pyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  Identification of amino acid appended acridines as potential leads to anti-cancer drugs

  摘要：

  In order to develop the amino acid appended acridines as potential leads for anticancer drugs, they were subjected to preliminary investigations. Screening through MTT assay as well as the phase contrast micrographs and Confocal images of immunostained C6 Glioma cells for markers such as alpha-tubulin, GFAP, mortalin and HSP-70 cells indicated that the compounds possess significant antiproliferative activity. The compounds also arrested cells in G0/G1 phase of the cell cycle as indicated by flow cytometry results. Moreover, the upregulation of the senescence markers such as mortalin and HSP70 in the presence of compounds 8, 9 and 12 indicate their senescence inducing potential. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.07.059

文献信息

• Identification of amino acid appended acridines as potential leads to anti-cancer drugs
  作者：Palwinder Singh、Arun Kumar、Anuradha Sharma、Gurcharan Kaur

  DOI：10.1016/j.bmcl.2015.07.059

  日期：2015.9

  In order to develop the amino acid appended acridines as potential leads for anticancer drugs, they were subjected to preliminary investigations. Screening through MTT assay as well as the phase contrast micrographs and Confocal images of immunostained C6 Glioma cells for markers such as alpha-tubulin, GFAP, mortalin and HSP-70 cells indicated that the compounds possess significant antiproliferative activity. The compounds also arrested cells in G0/G1 phase of the cell cycle as indicated by flow cytometry results. Moreover, the upregulation of the senescence markers such as mortalin and HSP70 in the presence of compounds 8, 9 and 12 indicate their senescence inducing potential. (C) 2015 Elsevier Ltd. All rights reserved.