5-[[2-(furan-2-ylmethylene)hydrazinyl](1H-imidazol-1-yl)methyl]thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[[2-(furan-2-ylmethylene)hydrazinyl](1H-imidazol-1-yl)methyl]thiazole
• 英文别名: 5-[[2-(Furan-2-ylmethylene)hydrazinyl](1h-imidazol-1-yl)methyl]thiazole；N-(furan-2-ylmethylideneamino)-1-imidazol-1-yl-1-(1,3-thiazol-5-yl)methanamine
• 化学式: C₁₂H₁₁N₅OS
• 分子量: 273.318
• InChiKey: BQJCKVSIWRWSQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  咪唑 、 5-噻唑甲醛 、 furfural hydrazone 在 二氯(1,10-菲咯啉)铜(II) 作用下， 以 乙醇 为溶剂， 生成 5-[[2-(furan-2-ylmethylene)hydrazinyl](1H-imidazol-1-yl)methyl]thiazole
  参考文献：
  名称：

  Synthesis of novel three compound imidazole derivatives via Cu(II) catalysis and their larvicidal and antimicrobial activities

  摘要：

  AbstractOne-pot three-component reactions of 1-[[2-(furan-2-ylmethylene)hydrazinyl](phenyl)methyl]-1H-imidazole and other imidazole derivatives were synthesized by Mannich base method in the presence of Cu(II) catalysis. Cu(Phen)Cl2 catalysis was performed well compared with other Cu(II) catalysis. Synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. Synthesized

  DOI：

  10.1007/s00706-016-1746-2

文献信息

• Synthesis of novel three compound imidazole derivatives via Cu(II) catalysis and their larvicidal and antimicrobial activities
  作者：Abdullah Alaklab、Radhakrishnan Surendra Kumar、Anis Ahamed、Ibrahim A. Arif、Aseer Manilal、Akbar Idhayadhulla

  DOI：10.1007/s00706-016-1746-2

  日期：2017.2

  dazole and other imidazole derivatives were synthesized by Mannich base method in the presence of Cu(II) catalysis. Cu(Phen)Cl2 catalysis was performed well compared with other Cu(II) catalysis. Synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. Synthesized compounds were evaluated by antimicrobial and larvicidal activities. 4-[[2-(Furan-2-ylmethylen

  AbstractOne-pot three-component reactions of 1-[[2-(furan-2-ylmethylene)hydrazinyl](phenyl)methyl]-1H-imidazole and other imidazole derivatives were synthesized by Mannich base method in the presence of Cu(II) catalysis. Cu(Phen)Cl2 catalysis was performed well compared with other Cu(II) catalysis. Synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. Synthesized