{3-([1-(isobutanoyloxy)ethoxy]carbonylamino)propyl}(n-butyl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {3-([1-(isobutanoyloxy)ethoxy]carbonylamino)propyl}(n-butyl)phosphinic acid
• 英文别名: 3-{[1-Isobutanoyloxyethoxy]carbonylamino}propyl(n-butyl)phosphinic Acid；butyl-[3-[1-(2-methylpropanoyloxy)ethoxycarbonylamino]propyl]phosphinic acid
• 化学式: C₁₄H₂₈NO₆P
• 分子量: 337.353
• InChiKey: BQKOMQWDKRJWIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-((2,5-双氧吡咯-1-氧基)羰基氧基异丁酸乙酯 、 3-aminopropyl(n-butyl)phosphinic acid 在 碳酸氢钠 、 potassium hydrogensulfate 、 水 作用下， 以 水 、 乙腈 、 乙酸乙酯 为溶剂， 反应 16.0h， 生成 {3-([1-(isobutanoyloxy)ethoxy]carbonylamino)propyl}(n-butyl)phosphinic acid
  参考文献：
  名称：

  WO2008/33572

  摘要：

  公开号：

文献信息

• Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
  申请人：Gallop Mark A.

  公开号：US20080146526A1

  公开（公告）日：2008-06-19

  Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

  本发明揭示了3-氨基丙基膦酸及其类似物的酰氧基烷基氨基甲酸酯前药，制备酰氧基烷基氨基甲酸酯前药的方法，使用酰氧基烷基氨基甲酸酯前药的方法，以及包含酰氧基烷基氨基甲酸酯前药的制药组合物，用于治疗轻度认知障碍、与阿尔茨海默病相关的认知障碍、抑郁症、焦虑症和癫痫等疾病或疾病。本发明还揭示了适用于口服和持续释放口服剂型的3-氨基丙基膦酸及其类似物的酰氧基烷基氨基甲酸酯前药。
• ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
  申请人：Gallop Mark A

  公开号：US20090286759A1

  公开（公告）日：2009-11-19

  Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

  本发明涉及3-氨基丙基膦酸及其类似物的酰氧基烷基氨基甲酸酯前药，制备酰氧基烷基氨基甲酸酯前药的方法，使用酰氧基烷基氨基甲酸酯前药的方法，以及包含酰氧基烷基氨基甲酸酯前药的制药组合物，用于治疗轻度认知障碍、与阿尔茨海默病相关的认知障碍、抑郁症、焦虑症和癫痫等疾病或疾病。本发明还涉及适用于口服和持续释放口服剂型的3-氨基丙基膦酸及其类似物的酰氧基烷基氨基甲酸酯前药。
• US7585996B2
  申请人：——

  公开号：US7585996B2

  公开（公告）日：2009-09-08
• US7749985B2
  申请人：——

  公开号：US7749985B2

  公开（公告）日：2010-07-06
• [EN] ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE<br/>[FR] PROMÉDICAMENTS À BASE DE CARBAMATE D'ACYLOXYALKYLE, PROCÉDÉS DE SYNTHÈSE ET UTILISATION
  申请人：XENOPORT INC

  公开号：WO2008033572A1

  公开（公告）日：2008-03-20

  [EN] Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3- aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and, analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs of 3- aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
  [FR] La présente invention concerne des promédicaments à base de carbamate d'acyloxyalkyle de l'acide 3-aminopropylphosphinique et leurs analogues, des procédés de fabrication des promédicaments à base de carbamate d'acyloxyalkyle de l'acide 3-aminopropylphosphinique et leurs analogues, des procédés d'utilisation des promédicaments à base de carbamate d'acyloxyalkyle de l'acide 3-aminopropylphosphinique et leurs analogues, ainsi que des compositions pharmaceutiques contenant les promédicaments à base de carbamate d'acyloxyalkyle de l'acide 3-aminopropylphosphinique et leurs analogues. Les promédicaments selon l'invention permettent de traiter des maladies ou des troubles tels qu'une déficience cognitive légère, une déficience cognitive associée à la maladie d'Alzheimer, la dépression, l'anxiété, et l'épilepsie. L'invention concerne également des promédicaments à base de carbamate d'acyloxyalkyle de l'acide 3-aminopropylphosphinique, et leurs analogues, appropriés à une administration orale ainsi que des formes de dosage orales à libération prolongée.